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10.1136/bmjpo-2021-001034 http://scihub22266oqcxt.onion/10.1136/bmjpo-2021-001034 33884312!8023747!33884312     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33884312&cmd=llinks): Failed to open stream: HTTP request failed! 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Incidence of Kawasaki disease before and during the COVID-19 pandemic: a retrospective cohort study in Japan |pdf=|usr=}}{{33884312}} gab.com Text Incidence of Kawasaki disease before and during the COVID-19 pandemic: a retrospective cohort study in Japan JO: BMJ Paediatr Open http://www.kidney.de/pget.php?&tw=1&pmid=33884312 #FOAvip BACKGROUND: Epidemiological studies in Kawasaki disease (KD) have suggested infectious aetiology. During the COVID-19 pandemic, measures for mitigating SARS-CoV-2 transmission also suppress the circulation of other contagious microorganisms. The primary objective is to compare the number and incidence of KD before and during the COVID-19 pandemic in Japan, and the secondary objective is to investigate temporal association between the KD epidemiology and activities of SARS-CoV-2 and other viral and bacterial infections. METHODS: A retrospective cohort study was conducted between 2016 and 2020 in Kobe, Japan. We collected information of hospitalised KD children in Kobe. Child population was identified through the resident registry system. Activity of COVID-19 and 11 other infectious diseases was derived from a public health monitoring system. Monthly change of KD incidence was analysed using a difference-in-difference regression model. RESULTS: Throughout the study period, 1027 KD children were identified. KD had begun to decline in April 2020, coinciding with the beginning of the COVID-19 pandemic. The number of KD cases (n=66) between April and December 2020 was 40% of the average in the same period in 2016-2019 (165/year). Annual KD incidence was 315, 300, 353, 347 and 188/100 000 children aged 0-4 years in 2016-2020, respectively. The difference-in-difference value of KD incidence was significantly reduced in the fourth quarter in 2020 (-15.8, 95% CI -28.0 to -3.5), compared with that in 2016-2019. Sentinel surveillance showed a marked decrease of all infectious diseases except exanthema subitum after the beginning of the COVID-19 pandemic. There were 86 COVID-19 cases aged <10 years and no KD children associated with COVID-19. CONCLUSION: This study showed that the number and incidence of KD was dramatically reduced during the COVID-19 pandemic in Japan. This change was temporally associated with decreased activities of various infectious diseases other than COVID-19, supporting the hypothesis of infection-triggered pathogenesis in KD. Twit Text FOAVip Incidence of Kawasaki disease before and during the COVID-19 pandemic: a retrospective cohort study in Japan ????BMJ Paediatr Open http://www.kidney.de/pget.php?&tw=1&pmid=33884312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33884312 #FOAvip English Wikipedia <ref>{{Cite pmid|33884312}}</ref> Incidence of Kawasaki disease before and during the COVID-19 pandemic: a retrospective cohort study in Japan #MMPMID33884312 Iio K; Matsubara K; Miyakoshi C; Ota K; Yamaoka R; Eguchi J; Matsumura O; Okutani T; Ueda I; Nishiyama M BMJ Paediatr Open 2021[]; 5 (1): e001034 PMID33884312show ga BACKGROUND: Epidemiological studies in Kawasaki disease (KD) have suggested infectious aetiology. During the COVID-19 pandemic, measures for mitigating SARS-CoV-2 transmission also suppress the circulation of other contagious microorganisms. The primary objective is to compare the number and incidence of KD before and during the COVID-19 pandemic in Japan, and the secondary objective is to investigate temporal association between the KD epidemiology and activities of SARS-CoV-2 and other viral and bacterial infections. METHODS: A retrospective cohort study was conducted between 2016 and 2020 in Kobe, Japan. We collected information of hospitalised KD children in Kobe. Child population was identified through the resident registry system. Activity of COVID-19 and 11 other infectious diseases was derived from a public health monitoring system. Monthly change of KD incidence was analysed using a difference-in-difference regression model. RESULTS: Throughout the study period, 1027 KD children were identified. KD had begun to decline in April 2020, coinciding with the beginning of the COVID-19 pandemic. The number of KD cases (n=66) between April and December 2020 was 40% of the average in the same period in 2016-2019 (165/year). Annual KD incidence was 315, 300, 353, 347 and 188/100 000 children aged 0-4 years in 2016-2020, respectively. The difference-in-difference value of KD incidence was significantly reduced in the fourth quarter in 2020 (-15.8, 95% CI -28.0 to -3.5), compared with that in 2016-2019. Sentinel surveillance showed a marked decrease of all infectious diseases except exanthema subitum after the beginning of the COVID-19 pandemic. There were 86 COVID-19 cases aged <10 years and no KD children associated with COVID-19. CONCLUSION: This study showed that the number and incidence of KD was dramatically reduced during the COVID-19 pandemic in Japan. This change was temporally associated with decreased activities of various infectious diseases other than COVID-19, supporting the hypothesis of infection-triggered pathogenesis in KD. |*COVID-19[MESH] |*Mucocutaneous Lymph Node Syndrome/epidemiology[MESH] |Child[MESH] |Child, Preschool[MESH] |Humans[MESH] |Incidence[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Japan/epidemiology[MESH] |Pandemics[MESH] |Retrospective Studies[MESH]Incidence of Kawasaki disease before and during the COVID-19 pandemic:(epmc).pdf DeepDyve Pubget Overpricing