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10.1038/s41379-021-00808-8 http://scihub22266oqcxt.onion/10.1038/s41379-021-00808-8 33883694!8058579!33883694     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mod+Pathol 2021 ; 34 (8): 1444-1455 Nephropedia Template TP {{tp|p=33883694|t=2021. The pathogenic role of epithelial and endothelial cells in early-phase COVID-19 pneumonia: victims and partners in crime |pdf=|usr=}}{{33883694}} gab.com Text The pathogenic role of epithelial and endothelial cells in early-phase COVID-19 pneumonia: victims and partners in crime JO: Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33883694 #FOAvip Current understanding of the complex pathogenesis of COVID-19 interstitial pneumonia pathogenesis in the light of biopsies carried out in early/moderate phase and histology data obtained at postmortem analysis is discussed. In autopsies the most observed pattern is diffuse alveolar damage with alveolar-epithelial type-II cell hyperplasia, hyaline membranes, and frequent thromboembolic disease. However, these observations cannot explain some clinical, radiological and physiopathological features observed in SARS-CoV-2 interstitial pneumonia, including the occurrence of vascular enlargement on CT and preserved lung compliance in subjects even presenting with or developing respiratory failure. Histological investigation on early-phase pneumonia on perioperative samples and lung biopsies revealed peculiar morphological and morpho-phenotypical changes including hyper-expression of phosphorylated STAT3 and immune checkpoint molecules (PD-L1 and IDO) in alveolar-epithelial and endothelial cells. These features might explain in part these discrepancies. Twit Text FOAVip The pathogenic role of epithelial and endothelial cells in early-phase COVID-19 pneumonia: victims and partners in crime ????Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33883694 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33883694 #FOAvip English Wikipedia <ref>{{Cite pmid|33883694}}</ref> The pathogenic role of epithelial and endothelial cells in early-phase COVID-19 pneumonia: victims and partners in crime #MMPMID33883694 Chilosi M; Poletti V; Ravaglia C; Rossi G; Dubini A; Piciucchi S; Pedica F; Bronte V; Pizzolo G; Martignoni G; Doglioni C Mod Pathol 2021[Aug]; 34 (8): 1444-1455 PMID33883694show ga Current understanding of the complex pathogenesis of COVID-19 interstitial pneumonia pathogenesis in the light of biopsies carried out in early/moderate phase and histology data obtained at postmortem analysis is discussed. In autopsies the most observed pattern is diffuse alveolar damage with alveolar-epithelial type-II cell hyperplasia, hyaline membranes, and frequent thromboembolic disease. However, these observations cannot explain some clinical, radiological and physiopathological features observed in SARS-CoV-2 interstitial pneumonia, including the occurrence of vascular enlargement on CT and preserved lung compliance in subjects even presenting with or developing respiratory failure. Histological investigation on early-phase pneumonia on perioperative samples and lung biopsies revealed peculiar morphological and morpho-phenotypical changes including hyper-expression of phosphorylated STAT3 and immune checkpoint molecules (PD-L1 and IDO) in alveolar-epithelial and endothelial cells. These features might explain in part these discrepancies. |*Cell Communication[MESH] |B7-H1 Antigen/metabolism[MESH] |Biopsy[MESH] |COVID-19/metabolism/mortality/*pathology/virology[MESH] |Cytokines/metabolism[MESH] |Endothelial Cells/metabolism/*pathology/virology[MESH] |Epithelial Cells/metabolism/*pathology/virology[MESH] |Humans[MESH] |Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism[MESH] |Lung/metabolism/*pathology/virology[MESH] |Phosphorylation[MESH] |Prognosis[MESH] |STAT3 Transcription Factor/metabolism[MESH]The pathogenic role of epithelial and endothelial cells in early-phase(epmc).pdf DeepDyve Pubget Overpricing