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10.1038/s41598-021-87703-z http://scihub22266oqcxt.onion/10.1038/s41598-021-87703-z 33883570!8060306!33883570     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 8570 Nephropedia Template TP {{tp|p=33883570|t=2021. Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient s lung cells |pdf=|usr=}}{{33883570}} gab.com Text Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient s lung cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33883570 #FOAvip Although a defective vitamin D endocrine system has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significance of the vitamin D endocrine system in SARS-CoV-2 pathobiology, computational approaches were applied to transcriptomic datasets from bronchoalveolar lavage fluid (BALF) cells of such patients or healthy individuals. Levels of vitamin D receptor, retinoid X receptor, and CYP27A1 in BALF cells of patients infected with SARS-CoV-2 were found to be reduced. Additionally, 107 differentially expressed, predominantly downregulated genes, as potentially modulated by vitamin D endocrine system, were identified in transcriptomic datasets from patient's cells. Further analysis of differentially expressed genes provided eight novel genes with a conserved motif with vitamin D-responsive elements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulated vitamin D endocrine system in SARS-CoV-2-infected cells. Protein-protein interaction network of differentially expressed vitamin D-modulated genes were enriched in the immune system, NF-kappaB/cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. In brief, the results presented here povide computational evidence to implicate a dysregulated vitamin D endocrine system in the pathobiology of SARS-CoV-2 infection. Twit Text FOAVip Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient s lung cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33883570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33883570 #FOAvip English Wikipedia <ref>{{Cite pmid|33883570}}</ref> Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient s lung cells #MMPMID33883570 George B; Amjesh R; Paul AM; Santhoshkumar TR; Pillai MR; Kumar R Sci Rep 2021[Apr]; 11 (1): 8570 PMID33883570show ga Although a defective vitamin D endocrine system has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significance of the vitamin D endocrine system in SARS-CoV-2 pathobiology, computational approaches were applied to transcriptomic datasets from bronchoalveolar lavage fluid (BALF) cells of such patients or healthy individuals. Levels of vitamin D receptor, retinoid X receptor, and CYP27A1 in BALF cells of patients infected with SARS-CoV-2 were found to be reduced. Additionally, 107 differentially expressed, predominantly downregulated genes, as potentially modulated by vitamin D endocrine system, were identified in transcriptomic datasets from patient's cells. Further analysis of differentially expressed genes provided eight novel genes with a conserved motif with vitamin D-responsive elements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulated vitamin D endocrine system in SARS-CoV-2-infected cells. Protein-protein interaction network of differentially expressed vitamin D-modulated genes were enriched in the immune system, NF-kappaB/cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. In brief, the results presented here povide computational evidence to implicate a dysregulated vitamin D endocrine system in the pathobiology of SARS-CoV-2 infection. |*Gene Regulatory Networks[MESH] |A549 Cells[MESH] |Bronchoalveolar Lavage Fluid/*chemistry[MESH] |COVID-19/*genetics/metabolism[MESH] |Case-Control Studies[MESH] |Cell Line[MESH] |Cholestanetriol 26-Monooxygenase/genetics[MESH] |Computational Biology/*methods[MESH] |Databases, Genetic[MESH] |Down-Regulation[MESH] |Gene Expression Profiling/*methods[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Humans[MESH] |Protein Interaction Maps[MESH] |Receptors, Calcitriol/genetics[MESH] |Retinoid X Receptors/genetics[MESH]Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 in(epmc).pdf DeepDyve Pubget Overpricing