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10.1101/2021.04.09.21255184

http://scihub22266oqcxt.onion/10.1101/2021.04.09.21255184
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suck abstract from ncbi


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pmid33880488      medRxiv 2021 ; ä (ä): ä
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  • Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21 31 locus #MMPMID33880488
  • Kasela S; Daniloski Z; Jordan TX; tenOever BR; Sanjana NE; Lappalainen T
  • medRxiv 2021[Apr]; ä (ä): ä PMID33880488show ga
  • To date the locus with the most robust human genetic association to COVID-19 susceptibility is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that mediate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology.
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