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10.1038/s41591-021-01329-2 http://scihub22266oqcxt.onion/10.1038/s41591-021-01329-2 33879890!8121667!33879890     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2021 ; 27 (5): 904-916 Nephropedia Template TP {{tp|p=33879890|t=2021. Single-cell multi-omics analysis of the immune response in COVID-19 |pdf=|usr=}}{{33879890}} gab.com Text Single-cell multi-omics analysis of the immune response in COVID-19 JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33879890 #FOAvip Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16(+)C1QA/B/C(+)) that sequester platelets and were predicted to replenish the alveolar macrophage pool in COVID-19. Early, uncommitted CD34(+) hematopoietic stem/progenitor cells were primed toward megakaryopoiesis, accompanied by expanded megakaryocyte-committed progenitors and increased platelet activation. Clonally expanded CD8(+) T cells and an increased ratio of CD8(+) effector T cells to effector memory T cells characterized severe disease, while circulating follicular helper T cells accompanied mild disease. We observed a relative loss of IgA2 in symptomatic disease despite an overall expansion of plasmablasts and plasma cells. Our study highlights the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy. Twit Text FOAVip Single-cell multi-omics analysis of the immune response in COVID-19 ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=33879890 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33879890 #FOAvip English Wikipedia <ref>{{Cite pmid|33879890}}</ref> Single-cell multi-omics analysis of the immune response in COVID-19 #MMPMID33879890 Stephenson E; Reynolds G; Botting RA; Calero-Nieto FJ; Morgan MD; Tuong ZK; Bach K; Sungnak W; Worlock KB; Yoshida M; Kumasaka N; Kania K; Engelbert J; Olabi B; Spegarova JS; Wilson NK; Mende N; Jardine L; Gardner LCS; Goh I; Horsfall D; McGrath J; Webb S; Mather MW; Lindeboom RGH; Dann E; Huang N; Polanski K; Prigmore E; Gothe F; Scott J; Payne RP; Baker KF; Hanrath AT; Schim van der Loeff ICD; Barr AS; Sanchez-Gonzalez A; Bergamaschi L; Mescia F; Barnes JL; Kilich E; de Wilton A; Saigal A; Saleh A; Janes SM; Smith CM; Gopee N; Wilson C; Coupland P; Coxhead JM; Kiselev VY; van Dongen S; Bacardit J; King HW; Rostron AJ; Simpson AJ; Hambleton S; Laurenti E; Lyons PA; Meyer KB; Nikolic MZ; Duncan CJA; Smith KGC; Teichmann SA; Clatworthy MR; Marioni JC; Gottgens B; Haniffa M Nat Med 2021[May]; 27 (5): 904-916 PMID33879890show ga Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16(+)C1QA/B/C(+)) that sequester platelets and were predicted to replenish the alveolar macrophage pool in COVID-19. Early, uncommitted CD34(+) hematopoietic stem/progenitor cells were primed toward megakaryopoiesis, accompanied by expanded megakaryocyte-committed progenitors and increased platelet activation. Clonally expanded CD8(+) T cells and an increased ratio of CD8(+) effector T cells to effector memory T cells characterized severe disease, while circulating follicular helper T cells accompanied mild disease. We observed a relative loss of IgA2 in symptomatic disease despite an overall expansion of plasmablasts and plasma cells. Our study highlights the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy. |*Proteome[MESH] |*Transcriptome[MESH] |COVID-19/*immunology[MESH] |Cross-Sectional Studies[MESH] |Humans[MESH] |Monocytes/immunology[MESH] |Receptors, Antigen, B-Cell/immunology[MESH] |Receptors, Antigen, T-Cell/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Single-Cell Analysis/*methods[MESH]Single-cell multi-omics analysis of the immune response in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing