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  • Single-cell multi-omics analysis of the immune response in COVID-19 #MMPMID33879890
  • Stephenson E; Reynolds G; Botting RA; Calero-Nieto FJ; Morgan MD; Tuong ZK; Bach K; Sungnak W; Worlock KB; Yoshida M; Kumasaka N; Kania K; Engelbert J; Olabi B; Spegarova JS; Wilson NK; Mende N; Jardine L; Gardner LCS; Goh I; Horsfall D; McGrath J; Webb S; Mather MW; Lindeboom RGH; Dann E; Huang N; Polanski K; Prigmore E; Gothe F; Scott J; Payne RP; Baker KF; Hanrath AT; Schim van der Loeff ICD; Barr AS; Sanchez-Gonzalez A; Bergamaschi L; Mescia F; Barnes JL; Kilich E; de Wilton A; Saigal A; Saleh A; Janes SM; Smith CM; Gopee N; Wilson C; Coupland P; Coxhead JM; Kiselev VY; van Dongen S; Bacardit J; King HW; Rostron AJ; Simpson AJ; Hambleton S; Laurenti E; Lyons PA; Meyer KB; Nikolic MZ; Duncan CJA; Smith KGC; Teichmann SA; Clatworthy MR; Marioni JC; Gottgens B; Haniffa M
  • Nat Med 2021[May]; 27 (5): 904-916 PMID33879890show ga
  • Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16(+)C1QA/B/C(+)) that sequester platelets and were predicted to replenish the alveolar macrophage pool in COVID-19. Early, uncommitted CD34(+) hematopoietic stem/progenitor cells were primed toward megakaryopoiesis, accompanied by expanded megakaryocyte-committed progenitors and increased platelet activation. Clonally expanded CD8(+) T cells and an increased ratio of CD8(+) effector T cells to effector memory T cells characterized severe disease, while circulating follicular helper T cells accompanied mild disease. We observed a relative loss of IgA2 in symptomatic disease despite an overall expansion of plasmablasts and plasma cells. Our study highlights the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy.
  • |*Proteome[MESH]
  • |*Transcriptome[MESH]
  • |COVID-19/*immunology[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Humans[MESH]
  • |Monocytes/immunology[MESH]
  • |Receptors, Antigen, B-Cell/immunology[MESH]
  • |Receptors, Antigen, T-Cell/immunology[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Single-Cell Analysis/*methods[MESH]
  • |T-Lymphocytes/immunology[MESH]

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  • suck abstract from ncbi

    904 5.27 2021