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10.1038/s41418-021-00782-3 http://scihub22266oqcxt.onion/10.1038/s41418-021-00782-3 33879858!8056997!33879858     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2021 ; 28 (9): 2765-2777 Nephropedia Template TP {{tp|p=33879858|t=2021. SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination |pdf=|usr=}}{{33879858}} gab.com Text SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=33879858 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is highly contagious and causes lymphocytopenia, but the underlying mechanisms are poorly understood. We demonstrate here that heterotypic cell-in-cell structures with lymphocytes inside multinucleate syncytia are prevalent in the lung tissues of coronavirus disease 2019 (COVID-19) patients. These unique cellular structures are a direct result of SARS-CoV-2 infection, as the expression of the SARS-CoV-2 spike glycoprotein is sufficient to induce a rapid (~45.1 nm/s) membrane fusion to produce syncytium, which could readily internalize multiple lines of lymphocytes to form typical cell-in-cell structures, remarkably leading to the death of internalized cells. This membrane fusion is dictated by a bi-arginine motif within the polybasic S1/S2 cleavage site, which is frequently present in the surface glycoprotein of most highly contagious viruses. Moreover, candidate anti-viral drugs could efficiently inhibit spike glycoprotein processing, membrane fusion, and cell-in-cell formation. Together, we delineate a molecular and cellular rationale for SARS-CoV-2 pathogenesis and identify novel targets for COVID-19 therapy. Twit Text FOAVip SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=33879858 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33879858 #FOAvip English Wikipedia <ref>{{Cite pmid|33879858}}</ref> SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination #MMPMID33879858 Zhang Z; Zheng Y; Niu Z; Zhang B; Wang C; Yao X; Peng H; Franca DN; Wang Y; Zhu Y; Su Y; Tang M; Jiang X; Ren H; He M; Wang Y; Gao L; Zhao P; Shi H; Chen Z; Wang X; Piacentini M; Bian X; Melino G; Liu L; Huang H; Sun Q Cell Death Differ 2021[Sep]; 28 (9): 2765-2777 PMID33879858show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is highly contagious and causes lymphocytopenia, but the underlying mechanisms are poorly understood. We demonstrate here that heterotypic cell-in-cell structures with lymphocytes inside multinucleate syncytia are prevalent in the lung tissues of coronavirus disease 2019 (COVID-19) patients. These unique cellular structures are a direct result of SARS-CoV-2 infection, as the expression of the SARS-CoV-2 spike glycoprotein is sufficient to induce a rapid (~45.1 nm/s) membrane fusion to produce syncytium, which could readily internalize multiple lines of lymphocytes to form typical cell-in-cell structures, remarkably leading to the death of internalized cells. This membrane fusion is dictated by a bi-arginine motif within the polybasic S1/S2 cleavage site, which is frequently present in the surface glycoprotein of most highly contagious viruses. Moreover, candidate anti-viral drugs could efficiently inhibit spike glycoprotein processing, membrane fusion, and cell-in-cell formation. Together, we delineate a molecular and cellular rationale for SARS-CoV-2 pathogenesis and identify novel targets for COVID-19 therapy. |COVID-19/pathology/*virology[MESH] |Cell Line[MESH] |Cell Line, Tumor[MESH] |Giant Cells/pathology/*virology[MESH] |HEK293 Cells[MESH] |HeLa Cells[MESH] |Humans[MESH] |Jurkat Cells[MESH] |K562 Cells[MESH] |Lymphocytes/pathology/*virology[MESH] |SARS-CoV-2/*metabolism/*pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/*metabolism[MESH] |Virus Internalization[MESH]SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimin(epmc).pdf DeepDyve Pubget Overpricing