Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.26355/eurrev_202104_25569

http://scihub22266oqcxt.onion/10.26355/eurrev_202104_25569
suck pdf from google scholar
33877683!8612127!33877683
unlimited free pdf from europmc33877683    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid33877683      Eur+Rev+Med+Pharmacol+Sci 2021 ; 25 (7): 3136-3144
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Dantrolene repurposed to treat sepsis or septic shock and COVID-19 patients #MMPMID33877683
  • Wei H; Liang G; Vera RM
  • Eur Rev Med Pharmacol Sci 2021[Apr]; 25 (7): 3136-3144 PMID33877683show ga
  • Disruption of intracellular Ca2+ homeostasis via excessive and pathological Ca2+ release from the endoplasmic reticulum (ER) and/or sarcoplasmic reticulum (SR) through ryanodine receptor (RyRs) Ca2+ channels play a critical role in the pathology of systemic inflammatory response syndrome (SIRS) and associated multiple organ dysfunction syndrome (MODS) in sepsis or septic shock. Dantrolene, a potent inhibitor of RyRs, is expected to ameliorate SIRS and MODS and decrease mortality in sepsis or septic shock patients. This review summarized the potential mechanisms of therapeutic effects of dantrolene in sepsis or septic shock at molecular, cell, and organ levels and provided suggestions and strategies for future clinical studies.
  • |*COVID-19 Drug Treatment[MESH]
  • |COVID-19/metabolism[MESH]
  • |Calcium Channel Blockers/*therapeutic use[MESH]
  • |Calcium/metabolism[MESH]
  • |Dantrolene/*therapeutic use[MESH]
  • |Drug Repositioning[MESH]
  • |Endoplasmic Reticulum/metabolism[MESH]
  • |Humans[MESH]
  • |Mortality[MESH]
  • |Multiple Organ Failure[MESH]
  • |Ryanodine Receptor Calcium Release Channel/metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |Sarcoplasmic Reticulum/metabolism[MESH]
  • |Sepsis/*drug therapy/metabolism[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box