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10.1038/s41598-021-87713-x http://scihub22266oqcxt.onion/10.1038/s41598-021-87713-x 33875719!8055906!33875719     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 8435 Nephropedia Template TP {{tp|p=33875719|t=2021. Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology |pdf=|usr=}}{{33875719}} gab.com Text Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33875719 #FOAvip Expansion of COVID-19 worldwide increases interest in unraveling genomic variations of novel SARS-CoV-2 virus. Metadata of 408,493 SARS-CoV-2 genomes submitted to GISAID database were analyzed with respect to genomic clades and their geographic, age, and gender distributions. Of the currently known SARS-CoV-2 clades, clade GR was the most prevalent worldwide followed by GV then GH. Chronological analysis revealed expansion in SARS-CoV-2 clades carrying D614G mutations with the predominance of the newest clade, GV, in the last three months. D614G clades prevail in countries with more COVID-19 cases. Of them, the clades GH and GR were more frequently recovered from severe or deceased COVID-19 cases. In contrast, G and GV clades showed a significantly higher prevalence among asymptomatic patients or those with mild disease. Metadata analysis showed higher (p < 0.05) prevalence of severe/deceased cases among males than females and predominance of GR clade in female patients. Furthermore, severe disease/death was more prevalent (p < 0.05) in elderly than in adults/children. Higher prevalence of the GV clade in children compared to other age groups was also evident. These findings uniquely provide a statistical evidence on the adaptation-driven evolution of SARS-CoV-2 leading to altered infectivity, virulence, and mortality. Twit Text FOAVip Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33875719 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33875719 #FOAvip English Wikipedia <ref>{{Cite pmid|33875719}}</ref> Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 epidemiology #MMPMID33875719 Hamed SM; Elkhatib WF; Khairalla AS; Noreddin AM Sci Rep 2021[Apr]; 11 (1): 8435 PMID33875719show ga Expansion of COVID-19 worldwide increases interest in unraveling genomic variations of novel SARS-CoV-2 virus. Metadata of 408,493 SARS-CoV-2 genomes submitted to GISAID database were analyzed with respect to genomic clades and their geographic, age, and gender distributions. Of the currently known SARS-CoV-2 clades, clade GR was the most prevalent worldwide followed by GV then GH. Chronological analysis revealed expansion in SARS-CoV-2 clades carrying D614G mutations with the predominance of the newest clade, GV, in the last three months. D614G clades prevail in countries with more COVID-19 cases. Of them, the clades GH and GR were more frequently recovered from severe or deceased COVID-19 cases. In contrast, G and GV clades showed a significantly higher prevalence among asymptomatic patients or those with mild disease. Metadata analysis showed higher (p < 0.05) prevalence of severe/deceased cases among males than females and predominance of GR clade in female patients. Furthermore, severe disease/death was more prevalent (p < 0.05) in elderly than in adults/children. Higher prevalence of the GV clade in children compared to other age groups was also evident. These findings uniquely provide a statistical evidence on the adaptation-driven evolution of SARS-CoV-2 leading to altered infectivity, virulence, and mortality. |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |COVID-19/epidemiology/*pathology/virology[MESH] |Child[MESH] |Coronavirus Nucleocapsid Proteins/genetics[MESH] |Coronavirus RNA-Dependent RNA Polymerase/genetics[MESH] |Databases, Factual[MESH] |Europe/epidemiology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Mutation[MESH] |North America/epidemiology[MESH] |SARS-CoV-2/*genetics/isolation & purification[MESH] |Sex Factors[MESH] |Spike Glycoprotein, Coronavirus/genetics[MESH]Global dynamics of SARS-CoV-2 clades and their relation to COVID-19 ep(epmc).pdf DeepDyve Pubget Overpricing