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10.4081/reumatismo.2021.1331

http://scihub22266oqcxt.onion/10.4081/reumatismo.2021.1331
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33874647!ä!33874647

suck abstract from ncbi


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pmid33874647      Reumatismo 2021 ; 73 (1): 48-53
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  • Children with Kawasaki disease or Kawasaki-like syndrome (MIS-C/PIMS) at the time of COVID-19: are they all the same? Case series and literature review #MMPMID33874647
  • Marino A; Varisco T; Quattrocchi G; Amoroso A; Beltrami D; Venturiello S; Ripamonti A; Villa A; Andreotti M; Ciuffreda M; Cimaz R
  • Reumatismo 2021[Apr]; 73 (1): 48-53 PMID33874647show ga
  • Since the coronavirus disease 2019 (COVID-19) outbreak started, children have been considered marginally involved compared to adults, with a quite significant percentage of asymptomatic carriers. Very recently, an overwhelming inflammatory activation, which shares clinical similarities with Kawasaki disease (KD), has been described in children exposed to COVID-19. We report three KD-like cases that occurred during the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a highly affected area of Northern Italy. The clinical presentation was characterized by the presence of unremitting fever, diarrhea and elevated inflammatory markers. Case #1 and Case #2 occurred one week apart and shared other clinical features: laboratory tests confirmed COVID-19 exposure and high inflammatory activation with myocardial involvement. Case #3 followed a more typical pattern for KD. Interestingly, this patient showed lower levels of procalcitonin, C-reactive protein, D-dimers, and ferritin compared to the other two cases, whereas platelet count was higher. We hypothesize that SARS-CoV-2 might act in children as a trigger, either inducing a classical KD phenotype or causing a systemic inflammatory response leading to a severe KD-like phenotype, eventually characterized by myocardial impairment. We think that bringing these cases and their differences to the attention of the rheumatology community during the COVID-19 pandemic will be beneficial in order to highlight the importance of early diagnosis and to increase awareness of this new phenomenon.
  • |COVID-19/*complications/diagnosis/etiology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Italy[MESH]
  • |Male[MESH]
  • |Mucocutaneous Lymph Node Syndrome/diagnosis/*etiology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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