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10.1016/j.compbiomed.2021.104380 http://scihub22266oqcxt.onion/10.1016/j.compbiomed.2021.104380 33872970!8049180!33872970     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33872970&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Comput+Biol+Med 2021 ; 133 (ä): 104380 Nephropedia Template TP {{tp|p=33872970|t=2021. A unique view of SARS-CoV-2 through the lens of ORF8 protein |pdf=|usr=}}{{33872970}} gab.com Text A unique view of SARS-CoV-2 through the lens of ORF8 protein JO: Comput Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=33872970 #FOAvip Immune evasion is one of the unique characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the adaptive host immunity through down-regulation of MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the host's interferon-mediated antiviral response. To understand the host's immune perspective in reference to the ORF8 protein, a comprehensive study of the ORF8 protein and mutations possessed by it have been performed. Chemical and structural properties of ORF8 proteins from different hosts, such as human, bat, and pangolin, suggest that the ORF8 of SARS-CoV-2 is much closer to ORF8 of Bat RaTG13-CoV than to that of Pangolin-CoV. Eighty-seven mutations across unique variants of ORF8 in SARS-CoV-2 can be grouped into four classes based on their predicted effects (Hussain et al., 2021) [1]. Based on the geo-locations and timescale of sample collection, a possible flow of mutations was built. Furthermore, conclusive flows of amalgamation of mutations were found upon sequence similarity analyses and consideration of the amino acid conservation phylogenies. Therefore, this study seeks to highlight the uniqueness of the rapidly evolving SARS-CoV-2 through the ORF8. Twit Text FOAVip A unique view of SARS-CoV-2 through the lens of ORF8 protein ????Comput Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=33872970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33872970 #FOAvip English Wikipedia <ref>{{Cite pmid|33872970}}</ref> A unique view of SARS-CoV-2 through the lens of ORF8 protein #MMPMID33872970 Hassan SS; Aljabali AAA; Panda PK; Ghosh S; Attrish D; Choudhury PP; Seyran M; Pizzol D; Adadi P; Abd El-Aziz TM; Soares A; Kandimalla R; Lundstrom K; Lal A; Azad GK; Uversky VN; Sherchan SP; Baetas-da-Cruz W; Uhal BD; Rezaei N; Chauhan G; Barh D; Redwan EM; Dayhoff GW 2nd; Bazan NG; Serrano-Aroca A; El-Demerdash A; Mishra YK; Palu G; Takayama K; Brufsky AM; Tambuwala MM Comput Biol Med 2021[Jun]; 133 (ä): 104380 PMID33872970show ga Immune evasion is one of the unique characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the adaptive host immunity through down-regulation of MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the host's interferon-mediated antiviral response. To understand the host's immune perspective in reference to the ORF8 protein, a comprehensive study of the ORF8 protein and mutations possessed by it have been performed. Chemical and structural properties of ORF8 proteins from different hosts, such as human, bat, and pangolin, suggest that the ORF8 of SARS-CoV-2 is much closer to ORF8 of Bat RaTG13-CoV than to that of Pangolin-CoV. Eighty-seven mutations across unique variants of ORF8 in SARS-CoV-2 can be grouped into four classes based on their predicted effects (Hussain et al., 2021) [1]. Based on the geo-locations and timescale of sample collection, a possible flow of mutations was built. Furthermore, conclusive flows of amalgamation of mutations were found upon sequence similarity analyses and consideration of the amino acid conservation phylogenies. Therefore, this study seeks to highlight the uniqueness of the rapidly evolving SARS-CoV-2 through the ORF8. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Evolution, Molecular[MESH] |Genome, Viral[MESH] |Humans[MESH]A unique view of SARS-CoV-2 through the lens of ORF8 protein (epmc).pdf DeepDyve Pubget Overpricing