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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Chim+Acta 2021 ; 519 (ä): 140-141 Nephropedia Template TP
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Methods matter - Tailoring SARS-CoV-2 antibody targets to vaccination status #MMPMID33872607
Rapp AR; Ogunbileje JO; Djouodo-Nemzou D; Okorodudu AO
Clin Chim Acta 2021[Aug]; 519 (ä): 140-141 PMID33872607show ga
Individuals who have been vaccinated for COVID19 should have IgG antibody in response to the specific antigen that is the target in the vaccine development. There are several options for targeted COVID19 antigen, but most manufacturers have focused on the spike protein. Using our understanding of the targeted antigen for vaccine development, we can develop testing algorithmic scheme for anti-spike and anti-nucleocapsid antibody assays to aid delineation of infection versus vaccination in our patient population. Clear communication from laboratories specifying the specific SARS-CoV-2 antibodies (i.e., anti-spike, anti-nucleocapsid, or both) in their antibody tests at both the ordering and reporting levels will play crucial role in the development of this approach and is essential to avoid potential provider/patient confusion in the interpretation of serologic testing.