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10.1097/INF.0000000000003149

http://scihub22266oqcxt.onion/10.1097/INF.0000000000003149
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33872279!8408805!33872279
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suck abstract from ncbi


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pmid33872279      Pediatr+Infect+Dis+J 2021 ; 40 (7): 601-605
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  • Multisystem Inflammatory Syndrome in Infants 12 months of Age, United States, May 2020-January 2021 #MMPMID33872279
  • Godfred-Cato S; Tsang CA; Giovanni J; Abrams J; Oster ME; Lee EH; Lash MK; Le Marchand C; Liu CY; Newhouse CN; Richardson G; Murray MT; Lim S; Haupt TE; Hartley A; Sosa LE; Ngamsnga K; Garcia A; Datta D; Belay ED
  • Pediatr Infect Dis J 2021[Jul]; 40 (7): 601-605 PMID33872279show ga
  • BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C), temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified in infants <12 months old. Clinical characteristics and follow-up data of MIS-C in infants have not been well described. We sought to describe the clinical course, laboratory findings, therapeutics and outcomes among infants diagnosed with MIS-C. METHODS: Infants of age <12 months with MIS-C were identified by reports to the CDC's MIS-C national surveillance system. Data were obtained on clinical signs and symptoms, complications, treatment, laboratory and imaging findings, and diagnostic SARS-CoV-2 testing. Jurisdictions that reported 2 or more infants were approached to participate in evaluation of outcomes of MIS-C. RESULTS: Eighty-five infants with MIS-C were identified and 83 (97.6%) tested positive for SARS-CoV-2 infection; median age was 7.7 months. Rash (62.4%), diarrhea (55.3%) and vomiting (55.3%) were the most common signs and symptoms reported. Other clinical findings included hypotension (21.2%), pneumonia (21.2%) and coronary artery dilatation or aneurysm (13.9%). Laboratory abnormalities included elevated C-reactive protein, ferritin, d-dimer and fibrinogen. Twenty-three infants had follow-up data; 3 of the 14 patients who received a follow-up echocardiogram had cardiac abnormalities during or after hospitalization. Nine infants had elevated inflammatory markers up to 98 days postdischarge. One infant (1.2%) died after experiencing multisystem organ failure secondary to MIS-C. CONCLUSIONS: Infants appear to have a milder course of MIS-C than older children with resolution of their illness after hospital discharge. The full clinical picture of MIS-C across the pediatric age spectrum is evolving.
  • |COVID-19 Testing/statistics & numerical data[MESH]
  • |COVID-19/diagnosis/*epidemiology/therapy[MESH]
  • |Epidemiological Monitoring[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Hospitalization/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Male[MESH]
  • |Systemic Inflammatory Response Syndrome/diagnosis/*epidemiology/therapy[MESH]


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