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10.1093/qjmed/hcab077

http://scihub22266oqcxt.onion/10.1093/qjmed/hcab077
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33871650!8083200!33871650
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suck abstract from ncbi


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pmid33871650      QJM 2021 ; 114 (8): 596-597
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  • Carnitine palmitoyltransferase II deficiency and post-COVID vaccination rhabdomyolysis #MMPMID33871650
  • Tan A; Stepien KM; Narayana STK
  • QJM 2021[Nov]; 114 (8): 596-597 PMID33871650show ga
  • Carnitine palmitoyltransferase II (CPT II) deficiency is a disorder affecting fatty acid oxidation. The myopathic form of the condition is the most common among adults and manifests itself with a high serum creatine kinase (CK) concentration. Triggers of very high CK concentrations include periods of fasting, infection, exercise, stress, and exposure to extreme temperatures. A 27-year-old man known to have CPT II deficiency presented feeling generally unwell after his COVID-19 vaccine. His CK concentration of 105,000 U/L and deranged liver function tests (ALT 300 U/L and AST 1496 U/L) were in keeping with rhabdomyolysis. His biochemical parameters and myopathy resolved with continuous intravenous dextrose 10% and a high carbohydrate diet. Caution should be exercised when administering vaccinations (including the COVID-19 vaccination) to this population. Clinicians should be wary for signs and symptoms of CPT II deficiency exacerbations and be vigilant in monitoring serum CK.
  • |*COVID-19[MESH]
  • |*Rhabdomyolysis/etiology[MESH]
  • |Carnitine O-Palmitoyltransferase/deficiency[MESH]
  • |Humans[MESH]
  • |Metabolism, Inborn Errors[MESH]
  • |SARS-CoV-2[MESH]


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