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10.1080/22221751.2021.1919032 http://scihub22266oqcxt.onion/10.1080/22221751.2021.1919032 33870851!8143642!33870851     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Emerg+Microbes+Infect 2021 ; 10 (1): 905-912 Nephropedia Template TP {{tp|p=33870851|t=2021. Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses |pdf=|usr=}}{{33870851}} gab.com Text Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses JO: Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33870851 #FOAvip Without an effective vaccine against SARS-CoV-2, the build-up of herd immunity through natural infection has been suggested as a means to control COVID-19. Although population immunity is typically estimated by the serological investigation of recovered patients, humoral immunity in asymptomatic subjects has not been well studied, although they represent a large proportion of all SARS-CoV-2 infection cases. In this study, we conducted a serosurvey of asymptomatic infections among food workers and performed serological and cellular response analyses of asymptomatic subjects in Wuhan, the original epicenter of the COVID-19 outbreak. Our data showed that up to 5.91% of the food workers carried SARS-CoV-2 IgG antibodies asymptomatically; however, in 90.4% of them, the antibody level declined over a 2-week period. IgM and IgG antibodies, including neutralizing antibodies, were significantly lower in asymptomatic subjects than in recovered symptomatic patients with similar disease courses. Furthermore, the asymptomatic subjects showed lymphopenia and a prominent decrease in the B-cell population, as well as a low frequency of antibody-secreting cells and a low cytokine response. These factors probably contributed to the low and unsustained antibody levels in asymptomatic subjects. Our results show that asymptomatic subjects are likely to be vulnerable to SARS-CoV-2 reinfection, and neither the proportion of population immunity nor the breadth of immune responses is sufficient for herd immunity. Twit Text FOAVip Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses ????Emerg Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=33870851 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33870851 #FOAvip English Wikipedia <ref>{{Cite pmid|33870851}}</ref> Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses #MMPMID33870851 Yang Y; Wang X; Du RH; Zhang W; Si HR; Zhu Y; Shen XR; Li Q; Li B; Men D; Zhou YN; Wang H; Tong XL; Zhang XE; Shi ZL; Zhou P Emerg Microbes Infect 2021[Dec]; 10 (1): 905-912 PMID33870851show ga Without an effective vaccine against SARS-CoV-2, the build-up of herd immunity through natural infection has been suggested as a means to control COVID-19. Although population immunity is typically estimated by the serological investigation of recovered patients, humoral immunity in asymptomatic subjects has not been well studied, although they represent a large proportion of all SARS-CoV-2 infection cases. In this study, we conducted a serosurvey of asymptomatic infections among food workers and performed serological and cellular response analyses of asymptomatic subjects in Wuhan, the original epicenter of the COVID-19 outbreak. Our data showed that up to 5.91% of the food workers carried SARS-CoV-2 IgG antibodies asymptomatically; however, in 90.4% of them, the antibody level declined over a 2-week period. IgM and IgG antibodies, including neutralizing antibodies, were significantly lower in asymptomatic subjects than in recovered symptomatic patients with similar disease courses. Furthermore, the asymptomatic subjects showed lymphopenia and a prominent decrease in the B-cell population, as well as a low frequency of antibody-secreting cells and a low cytokine response. These factors probably contributed to the low and unsustained antibody levels in asymptomatic subjects. Our results show that asymptomatic subjects are likely to be vulnerable to SARS-CoV-2 reinfection, and neither the proportion of population immunity nor the breadth of immune responses is sufficient for herd immunity. |*Asymptomatic Infections[MESH] |*COVID-19 Serological Testing[MESH] |*Pandemics[MESH] |Antibodies, Neutralizing/biosynthesis/*blood[MESH] |Antibodies, Viral/biosynthesis/*blood[MESH] |B-Lymphocytes[MESH] |COVID-19 Nucleic Acid Testing[MESH] |COVID-19/epidemiology/*immunology[MESH] |China/epidemiology[MESH] |Convalescence[MESH] |Cytokines/blood[MESH] |Disease Susceptibility[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Follow-Up Studies[MESH] |Food Handling[MESH] |Genome, Viral[MESH] |Humans[MESH] |Immunity, Herd[MESH] |Immunoglobulin G/biosynthesis/*blood[MESH] |Immunoglobulin M/biosynthesis/*blood[MESH] |Lymphocyte Count[MESH] |Lymphopenia/etiology[MESH] |Phylogeny[MESH] |RNA, Viral/blood[MESH] |Real-Time Polymerase Chain Reaction[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Seroepidemiologic Studies[MESH]Serological investigation of asymptomatic cases of SARS-CoV-2 infectio(epmc).pdf DeepDyve Pubget Overpricing