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10.3389/fphys.2021.663869 http://scihub22266oqcxt.onion/10.3389/fphys.2021.663869 33868029!8047414!33868029     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33868029&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Front+Physiol 2021 ; 12 (?): 663869 Nephropedia Template TP {{tp|p=33868029|t=2021. Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections |pdf=|usr=}}{{33868029}} gab.com Text Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33868029 #FOAvip Polyunsaturated fatty acids are metabolized into regulatory lipids important for initiating inflammatory responses in the event of disease or injury and for signaling the resolution of inflammation and return to homeostasis. The epoxides of linoleic acid (leukotoxins) regulate skin barrier function, perivascular and alveolar permeability and have been associated with poor outcomes in burn patients and in sepsis. It was later reported that blocking metabolism of leukotoxins into the vicinal diols ameliorated the deleterious effects of leukotoxins, suggesting that the leukotoxin diols are contributing to the toxicity. During quantitative profiling of fatty acid chemical mediators (eicosanoids) in COVID-19 patients, we found increases in the regioisomeric leukotoxin diols in plasma samples of hospitalized patients suffering from severe pulmonary involvement. In rodents these leukotoxin diols cause dramatic vascular permeability and are associated with acute adult respiratory like symptoms. Thus, pathways involved in the biosynthesis and degradation of these regulatory lipids should be investigated in larger biomarker studies to determine their significance in COVID-19 disease. In addition, incorporating diols in plasma multi-omics of patients could illuminate the COVID-19 pathological signature along with other lipid mediators and blood chemistry. Twit Text FOAVip Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33868029 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33868029 #FOAvip English Wikipedia <ref>{{Cite pmid|33868029}}</ref> Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections #MMPMID33868029 McReynolds CB; Cortes-Puch I; Ravindran R; Khan IH; Hammock BG; Shih PB; Hammock BD; Yang J Front Physiol 2021[]; 12 (?): 663869 PMID33868029show ga Polyunsaturated fatty acids are metabolized into regulatory lipids important for initiating inflammatory responses in the event of disease or injury and for signaling the resolution of inflammation and return to homeostasis. The epoxides of linoleic acid (leukotoxins) regulate skin barrier function, perivascular and alveolar permeability and have been associated with poor outcomes in burn patients and in sepsis. It was later reported that blocking metabolism of leukotoxins into the vicinal diols ameliorated the deleterious effects of leukotoxins, suggesting that the leukotoxin diols are contributing to the toxicity. During quantitative profiling of fatty acid chemical mediators (eicosanoids) in COVID-19 patients, we found increases in the regioisomeric leukotoxin diols in plasma samples of hospitalized patients suffering from severe pulmonary involvement. In rodents these leukotoxin diols cause dramatic vascular permeability and are associated with acute adult respiratory like symptoms. Thus, pathways involved in the biosynthesis and degradation of these regulatory lipids should be investigated in larger biomarker studies to determine their significance in COVID-19 disease. In addition, incorporating diols in plasma multi-omics of patients could illuminate the COVID-19 pathological signature along with other lipid mediators and blood chemistry. ?Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 In(epmc).pdf DeepDyve Pubget Overpricing