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10.1038/s41431-021-00886-x http://scihub22266oqcxt.onion/10.1038/s41431-021-00886-x 33867526!8053565!33867526     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Hum+Genet 2021 ; 29 (8): 1312-1315 Nephropedia Template TP {{tp|p=33867526|t=2021. Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms |pdf=|usr=}}{{33867526}} gab.com Text Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms JO: Eur J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=33867526 #FOAvip Critically ill coronavirus disease 2019 (COVID-19) is characterized by severe cytokine storms, a hyperinflammatory condition intimately related to the development of fatal outcomes. Why some individuals seem particularly vulnerable to severe cytokine storms is still unknown. Primary immunodeficiency (PID)-related genes are inherited factors that dysregulate host inflammatory responses to infection, especially hemophagocytic lymphohistiocytosis (HLH)-related genes, established as contributors to the development of excessive cytokine storms. We analyzed the association between PID gene variants with severe cytokine storms in COVID-19. We conducted whole-exome sequencing in 233 hospitalized COVID-19 patients and identified four PID gene (UNC13D, AP3B1, RNF168, DHX58) variants were significantly enriched in COVID-19 patients experiencing severe cytokine storms. The total percentage of COVID-19 patients with variants in UNC13D or AP3B1, two typical HLH genes, was dramatically higher in high-level cytokine group than in low-level group (33.3 vs. 5.7%, P < 0.001). Germline variants in UNC13D and AP3B1 were associated with the development of severe cytokine storms, fatal outcomes in COVID-19. These findings advance the understanding of individual susceptibility to severe cytokine storms and help optimize the current management of COVID-19. Twit Text FOAVip Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms ????Eur J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=33867526 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33867526 #FOAvip English Wikipedia <ref>{{Cite pmid|33867526}}</ref> Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms #MMPMID33867526 Luo H; Liu D; Liu W; Wang G; Chen L; Cao Y; Wei J; Xiao M; Liu X; Huang G; Wang W; Zhou J; Wang QF Eur J Hum Genet 2021[Aug]; 29 (8): 1312-1315 PMID33867526show ga Critically ill coronavirus disease 2019 (COVID-19) is characterized by severe cytokine storms, a hyperinflammatory condition intimately related to the development of fatal outcomes. Why some individuals seem particularly vulnerable to severe cytokine storms is still unknown. Primary immunodeficiency (PID)-related genes are inherited factors that dysregulate host inflammatory responses to infection, especially hemophagocytic lymphohistiocytosis (HLH)-related genes, established as contributors to the development of excessive cytokine storms. We analyzed the association between PID gene variants with severe cytokine storms in COVID-19. We conducted whole-exome sequencing in 233 hospitalized COVID-19 patients and identified four PID gene (UNC13D, AP3B1, RNF168, DHX58) variants were significantly enriched in COVID-19 patients experiencing severe cytokine storms. The total percentage of COVID-19 patients with variants in UNC13D or AP3B1, two typical HLH genes, was dramatically higher in high-level cytokine group than in low-level group (33.3 vs. 5.7%, P < 0.001). Germline variants in UNC13D and AP3B1 were associated with the development of severe cytokine storms, fatal outcomes in COVID-19. These findings advance the understanding of individual susceptibility to severe cytokine storms and help optimize the current management of COVID-19. |Adaptor Protein Complex 3/*genetics/metabolism[MESH] |Adaptor Protein Complex beta Subunits/*genetics/metabolism[MESH] |Aged[MESH] |COVID-19/*genetics/immunology/metabolism/*pathology[MESH] |Cytokine Release Syndrome/genetics[MESH] |Humans[MESH] |Lymphohistiocytosis, Hemophagocytic/genetics[MESH] |Membrane Proteins/*genetics/metabolism[MESH]Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patient(epmc).pdf DeepDyve Pubget Overpricing