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10.1016/j.ebiom.2021.103339

http://scihub22266oqcxt.onion/10.1016/j.ebiom.2021.103339
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33867313!8047083!33867313
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suck abstract from ncbi


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pmid33867313      EBioMedicine 2021 ; 66 (ä): 103339
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  • Epigenome-wide association study of COVID-19 severity with respiratory failure #MMPMID33867313
  • Castro de Moura M; Davalos V; Planas-Serra L; Alvarez-Errico D; Arribas C; Ruiz M; Aguilera-Albesa S; Troya J; Valencia-Ramos J; Velez-Santamaria V; Rodriguez-Palmero A; Villar-Garcia J; Horcajada JP; Albu S; Casasnovas C; Rull A; Reverte L; Dietl B; Dalmau D; Arranz MJ; Llucia-Carol L; Planas AM; Perez-Tur J; Fernandez-Cadenas I; Villares P; Tenorio J; Colobran R; Martin-Nalda A; Soler-Palacin P; Vidal F; Pujol A; Esteller M
  • EBioMedicine 2021[Apr]; 66 (ä): 103339 PMID33867313show ga
  • BACKGROUND: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the regulation of viral infections and the immune system, we performed an epigenome-wide association study (EWAS) to identify candidate loci regulated by this epigenetic mark that could be involved in the onset of COVID-19 in patients without comorbidities. METHODS: Peripheral blood samples were obtained from 407 confirmed COVID-19 patients
  • |*DNA Methylation[MESH]
  • |*Epigenome[MESH]
  • |Adult[MESH]
  • |COVID-19/etiology/*genetics[MESH]
  • |Cohort Studies[MESH]
  • |CpG Islands[MESH]
  • |Female[MESH]
  • |Genome-Wide Association Study[MESH]
  • |Humans[MESH]
  • |Interferons/genetics/metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Reproducibility of Results[MESH]
  • |Respiratory Insufficiency/genetics/*virology[MESH]
  • |Severity of Illness Index[MESH]
  • |Spain[MESH]


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