Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ebiom.2021.103339 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2021.103339 33867313!8047083!33867313     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33867313&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33867313.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EBioMedicine 2021 ; 66 (ä): 103339 Nephropedia Template TP {{tp|p=33867313|t=2021. Epigenome-wide association study of COVID-19 severity with respiratory failure |pdf=|usr=}}{{33867313}} gab.com Text Epigenome-wide association study of COVID-19 severity with respiratory failure JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=33867313 #FOAvip BACKGROUND: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the regulation of viral infections and the immune system, we performed an epigenome-wide association study (EWAS) to identify candidate loci regulated by this epigenetic mark that could be involved in the onset of COVID-19 in patients without comorbidities. METHODS: Peripheral blood samples were obtained from 407 confirmed COVID-19 patients </= 61 years of age and without comorbidities, 194 (47.7%) of whom had mild symptomatology that did not involve hospitalization and 213 (52.3%) had a severe clinical course that required respiratory support. The set of cases was divided into discovery (n = 207) and validation (n = 200) cohorts, balanced for age and sex of individuals. We analysed the DNA methylation status of 850,000 CpG sites in these patients. FINDINGS: The DNA methylation status of 44 CpG sites was associated with the clinical severity of COVID-19. Of these loci, 23 (52.3%) were located in 20 annotated coding genes. These genes, such as the inflammasome component Absent in Melanoma 2 (AIM2) and the Major Histocompatibility Complex, class I C (HLA-C) candidates, were mainly involved in the response of interferon to viral infection. We used the EWAS-identified sites to establish a DNA methylation signature (EPICOVID) that is associated with the severity of the disease. INTERPRETATION: We identified DNA methylation sites as epigenetic susceptibility loci for respiratory failure in COVID-19 patients. These candidate biomarkers, combined with other clinical, cellular and genetic factors, could be useful in the clinical stratification and management of patients infected with the SARS-CoV-2. FUNDING: The Unstoppable campaign of the Josep Carreras Leukaemia Foundation, the Cellex Foundation and the CERCA Programme/Generalitat de Catalunya. Twit Text FOAVip Epigenome-wide association study of COVID-19 severity with respiratory failure ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=33867313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33867313 #FOAvip English Wikipedia <ref>{{Cite pmid|33867313}}</ref> Epigenome-wide association study of COVID-19 severity with respiratory failure #MMPMID33867313 Castro de Moura M; Davalos V; Planas-Serra L; Alvarez-Errico D; Arribas C; Ruiz M; Aguilera-Albesa S; Troya J; Valencia-Ramos J; Velez-Santamaria V; Rodriguez-Palmero A; Villar-Garcia J; Horcajada JP; Albu S; Casasnovas C; Rull A; Reverte L; Dietl B; Dalmau D; Arranz MJ; Llucia-Carol L; Planas AM; Perez-Tur J; Fernandez-Cadenas I; Villares P; Tenorio J; Colobran R; Martin-Nalda A; Soler-Palacin P; Vidal F; Pujol A; Esteller M EBioMedicine 2021[Apr]; 66 (ä): 103339 PMID33867313show ga BACKGROUND: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the regulation of viral infections and the immune system, we performed an epigenome-wide association study (EWAS) to identify candidate loci regulated by this epigenetic mark that could be involved in the onset of COVID-19 in patients without comorbidities. METHODS: Peripheral blood samples were obtained from 407 confirmed COVID-19 patients |*DNA Methylation[MESH] |*Epigenome[MESH] |Adult[MESH] |COVID-19/etiology/*genetics[MESH] |Cohort Studies[MESH] |CpG Islands[MESH] |Female[MESH] |Genome-Wide Association Study[MESH] |Humans[MESH] |Interferons/genetics/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Reproducibility of Results[MESH] |Respiratory Insufficiency/genetics/*virology[MESH] |Severity of Illness Index[MESH] |Spain[MESH]Epigenome-wide association study of COVID-19 severity with respiratory(epmc).pdf DeepDyve Pubget Overpricing