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A fatal case of COVID-19-associated invasive pulmonary aspergillosis #MMPMID33867266
Iwanaga Y; Kawanami T; Yamasaki K; Sakakibara H; Ikushima I; Ikegami H; Tahara M; Akata K; Mukae H; Yatera K
J Infect Chemother 2021[Jul]; 27 (7): 1102-1107 PMID33867266show ga
A 79-year-old Japanese man with polymyalgia rheumatica was admitted to hospital with coronavirus disease (COVID-19). On admission, he was treated with ciclesonide inhalation, ivermectin, and meropenem. He was intubated 6 days after admission, and methylprednisolone therapy was initiated (1000 mg/day). Hypoxemia and chest radiographic findings temporarily improved. However, chest computed tomography showed bilateral ground-glass attenuations, multiple nodules, and consolidation. Aspergillus fumigatus was cultured from the tracheal aspirate and he was diagnosed with COVID-19-associated invasive pulmonary aspergillosis (CAPA) and treated with liposomal amphotericin B. However, he died 28 days after admission.