Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/febs.15881 http://scihub22266oqcxt.onion/10.1111/febs.15881 33864728!8250131!33864728     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33864728&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33864728.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FEBS+J 2021 ; 288 (17): 5148-5162 Nephropedia Template TP {{tp|p=33864728|t=2021. Host PDZ-containing proteins targeted by SARS-CoV-2 |pdf=|usr=}}{{33864728}} gab.com Text Host PDZ-containing proteins targeted by SARS-CoV-2 JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33864728 #FOAvip Small linear motifs targeting protein interacting domains called PSD-95/Dlg/ZO-1 (PDZ) have been identified at the C terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins E, 3a, and N. Using a high-throughput approach of affinity-profiling against the full human PDZome, we identified sixteen human PDZ binders of SARS-CoV-2 proteins E, 3A, and N showing significant interactions with dissociation constants values ranging from 3 to 82 mum. Six of them (TJP1, PTPN13, HTRA1, PARD3, MLLT4, LNX2) are also recognized by SARS-CoV while three (NHERF1, MAST2, RADIL) are specific to SARS-CoV-2 E protein. Most of these SARS-CoV-2 protein partners are involved in cellular junctions/polarity and could be also linked to evasion mechanisms of the immune responses during viral infection. Among the binders of the SARS-CoV-2 proteins E, 3a, or N, seven significantly affect viral replication under knock down gene expression in infected cells. This PDZ profiling identifying human proteins potentially targeted by SARS-CoV-2 can help to understand the multifactorial severity of COVID19 and to conceive effective anti-coronaviral agents for therapeutic purposes. Twit Text FOAVip Host PDZ-containing proteins targeted by SARS-CoV-2 ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33864728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33864728 #FOAvip English Wikipedia <ref>{{Cite pmid|33864728}}</ref> Host PDZ-containing proteins targeted by SARS-CoV-2 #MMPMID33864728 Caillet-Saguy C; Durbesson F; Rezelj VV; Gogl G; Tran QD; Twizere JC; Vignuzzi M; Vincentelli R; Wolff N FEBS J 2021[Sep]; 288 (17): 5148-5162 PMID33864728show ga Small linear motifs targeting protein interacting domains called PSD-95/Dlg/ZO-1 (PDZ) have been identified at the C terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins E, 3a, and N. Using a high-throughput approach of affinity-profiling against the full human PDZome, we identified sixteen human PDZ binders of SARS-CoV-2 proteins E, 3A, and N showing significant interactions with dissociation constants values ranging from 3 to 82 mum. Six of them (TJP1, PTPN13, HTRA1, PARD3, MLLT4, LNX2) are also recognized by SARS-CoV while three (NHERF1, MAST2, RADIL) are specific to SARS-CoV-2 E protein. Most of these SARS-CoV-2 protein partners are involved in cellular junctions/polarity and could be also linked to evasion mechanisms of the immune responses during viral infection. Among the binders of the SARS-CoV-2 proteins E, 3a, or N, seven significantly affect viral replication under knock down gene expression in infected cells. This PDZ profiling identifying human proteins potentially targeted by SARS-CoV-2 can help to understand the multifactorial severity of COVID19 and to conceive effective anti-coronaviral agents for therapeutic purposes. |COVID-19/*genetics/virology[MESH] |Carrier Proteins/genetics[MESH] |Coronavirus Nucleocapsid Proteins/genetics[MESH] |Host-Pathogen Interactions/*genetics[MESH] |Humans[MESH] |Kinesins/genetics[MESH] |Myosins/genetics[MESH] |PDZ Domains/*genetics[MESH] |Protein Binding/genetics[MESH] |Protein Interaction Domains and Motifs/genetics[MESH] |Protein Tyrosine Phosphatase, Non-Receptor Type 13/genetics[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH] |Viral Envelope Proteins/genetics[MESH] |Viroporin Proteins/genetics[MESH] |Virus Internalization[MESH] |Virus Replication/genetics[MESH]Host PDZ-containing proteins targeted by SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing