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10.1038/s41467-021-22580-8 http://scihub22266oqcxt.onion/10.1038/s41467-021-22580-8 33863887!8052374!33863887     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 2295 Nephropedia Template TP {{tp|p=33863887|t=2021. Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model |pdf=|usr=}}{{33863887}} gab.com Text Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33863887 #FOAvip The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic. Herein, we show that MK-4482, an orally administered nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model. The inhibitory effect of MK-4482 on SARS-CoV-2 replication is observed in animals when the drug is administered either beginning 12 h before or 12 h following infection in a high-risk exposure model. These data support the potential utility of MK-4482 to control SARS-CoV-2 infection in humans following high-risk exposure as well as for treatment of COVID-19 patients. Twit Text FOAVip Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33863887 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33863887 #FOAvip English Wikipedia <ref>{{Cite pmid|33863887}}</ref> Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model #MMPMID33863887 Rosenke K; Hansen F; Schwarz B; Feldmann F; Haddock E; Rosenke R; Barbian K; Meade-White K; Okumura A; Leventhal S; Hawman DW; Ricotta E; Bosio CM; Martens C; Saturday G; Feldmann H; Jarvis MA Nat Commun 2021[Apr]; 12 (1): 2295 PMID33863887show ga The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic. Herein, we show that MK-4482, an orally administered nucleoside analog, inhibits SARS-CoV-2 replication in the Syrian hamster model. The inhibitory effect of MK-4482 on SARS-CoV-2 replication is observed in animals when the drug is administered either beginning 12 h before or 12 h following infection in a high-risk exposure model. These data support the potential utility of MK-4482 to control SARS-CoV-2 infection in humans following high-risk exposure as well as for treatment of COVID-19 patients. |*COVID-19 Drug Treatment[MESH] |Administration, Oral[MESH] |Animals[MESH] |Antiviral Agents/*administration & dosage[MESH] |COVID-19/virology[MESH] |Chlorocebus aethiops[MESH] |Cytidine/administration & dosage/*analogs & derivatives[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Hydroxylamines/*administration & dosage[MESH] |Mesocricetus[MESH] |SARS-CoV-2/*drug effects/isolation & purification/physiology[MESH] |Vero Cells[MESH]Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian(epmc).pdf DeepDyve Pubget Overpricing