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10.1016/j.carrev.2021.03.023 http://scihub22266oqcxt.onion/10.1016/j.carrev.2021.03.023 33863660!8026249!33863660     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33863660&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cardiovasc+Revasc+Med 2022 ; 35 (ä): 129-138 Nephropedia Template TP {{tp|p=33863660|t=2022. Effects of Simulated COVID-19 Cytokine Storm on Stent Thrombogenicity |pdf=|usr=}}{{33863660}} gab.com Text Effects of Simulated COVID-19 Cytokine Storm on Stent Thrombogenicity JO: Cardiovasc Revasc Med http://www.kidney.de/pget.php?&tw=1&pmid=33863660 #FOAvip BACKGROUND: Cytokine storm-related hypercoagulation may be important in the pathogenesis of stent thrombosis in patients with SARS-CoV-2. Whether stent polymers behave differently under such conditions has never been explored. METHODS: Fluorinated polymer-nanocoated and uncoated COBRA stents (CeloNova), BioLinx-polymer-coated Resolute Onyx stents (Medtronic), and Synergy stents (Boston Scientific), which are abluminally coated with a bioabsorbable polymer, were exposed to human blood from healthy donors which was supplemented with 400 pg/mL IL-6 and 100 pg/mL TNF-alpha, similar to what is seen in cytokine storm caused by SARS-CoV-2. Platelet adhesion and neutrophil activation, assessed by immunofluorescence, were compared under cytokine storm and control conditions (untreated blood) (n = 4 experimental runs). RESULTS: Platelet adhesion values, defined as %platelet-covered area x staining intensity, were significantly lower in coated and uncoated COBRA and in Resolute Onyx than in Synergy under control conditions (1.28 x 10(7) +/- 0.43 x 10(7) vs. 2.92 x 10(7) +/- 0.49 x 10(7) vs. 3.57 x 10(7) +/- 0.73 x 10(7) vs. 9.94 x 10(7) +/- 0.99 x 10(7); p </=0.0001). In cytokine storm, platelet adhesion values remained low in coated COBRA-PzF (1.78 x 10(7) +/- 0.38 x 10(7)) compared to all other devices (uncoated COBRA: 5.92 x 10(7) +/- 0.96 x 10(7); Resolute Onyx: 7.27 x 10(7) +/- 1.82 x 10(7); Synergy: 11.28 x 10(7) +/- 1.08 x 10(7); p </= 0.0001). Although cytokine storm conditions significantly increased neutrophil activation in all stents, it was significantly less in coated and uncoated COBRA, and in Resolute Onyx than in Synergy. CONCLUSIONS: Blood-biomaterials interactions may determine the thrombogenic potential of stents. Under simulated cytokine storm conditions, fluoropolymer-coated stents showed the most favorable anti-thrombogenic and anti-inflammatory properties. Twit Text FOAVip Effects of Simulated COVID-19 Cytokine Storm on Stent Thrombogenicity ????Cardiovasc Revasc Med http://www.kidney.de/pget.php?&tw=1&pmid=33863660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33863660 #FOAvip English Wikipedia <ref>{{Cite pmid|33863660}}</ref> Effects of Simulated COVID-19 Cytokine Storm on Stent Thrombogenicity #MMPMID33863660 Cornelissen A; Kutyna M; Cheng Q; Sato Y; Kawakami R; Sakamoto A; Kawai K; Mori M; Fernandez R; Guo L; Pellegrini D; Guagliumi G; Barakat M; Virmani R; Finn A Cardiovasc Revasc Med 2022[Feb]; 35 (ä): 129-138 PMID33863660show ga BACKGROUND: Cytokine storm-related hypercoagulation may be important in the pathogenesis of stent thrombosis in patients with SARS-CoV-2. Whether stent polymers behave differently under such conditions has never been explored. METHODS: Fluorinated polymer-nanocoated and uncoated COBRA stents (CeloNova), BioLinx-polymer-coated Resolute Onyx stents (Medtronic), and Synergy stents (Boston Scientific), which are abluminally coated with a bioabsorbable polymer, were exposed to human blood from healthy donors which was supplemented with 400 pg/mL IL-6 and 100 pg/mL TNF-alpha, similar to what is seen in cytokine storm caused by SARS-CoV-2. Platelet adhesion and neutrophil activation, assessed by immunofluorescence, were compared under cytokine storm and control conditions (untreated blood) (n = 4 experimental runs). RESULTS: Platelet adhesion values, defined as %platelet-covered area x staining intensity, were significantly lower in coated and uncoated COBRA and in Resolute Onyx than in Synergy under control conditions (1.28 x 10(7) +/- 0.43 x 10(7) vs. 2.92 x 10(7) +/- 0.49 x 10(7) vs. 3.57 x 10(7) +/- 0.73 x 10(7) vs. 9.94 x 10(7) +/- 0.99 x 10(7); p |*COVID-19[MESH] |*Cytokine Release Syndrome[MESH] |Humans[MESH] |Prosthesis Design[MESH] |SARS-CoV-2[MESH]Effects of Simulated COVID-19 Cytokine Storm on Stent Thrombogenicity (epmc).pdf DeepDyve Pubget Overpricing