Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.celrep.2021.109017 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.109017 33857422!8018833!33857422     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 35 (3): 109017 Nephropedia Template TP {{tp|p=33857422|t=2021. SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization |pdf=|usr=}}{{33857422}} gab.com Text SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33857422 #FOAvip Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to farmed mink has been observed in Europe and the US. In the infected animals, viral variants arose that harbored mutations in the spike (S) protein, the target of neutralizing antibodies, and these variants were transmitted back to humans. This raised concerns that mink might become a constant source of human infection with SARS-CoV-2 variants associated with an increased threat to human health and resulted in mass culling of mink. Here, we report that mutations frequently found in the S proteins of SARS-CoV-2 from mink are mostly compatible with efficient entry into human cells and its inhibition by soluble angiotensin-converting enzyme 2 (ACE2). In contrast, mutation Y453F reduces neutralization by an antibody with emergency use authorization for coronavirus disease 2019 (COVID-19) therapy and sera/plasma from COVID-19 patients. These results suggest that antibody responses induced upon infection or certain antibodies used for treatment might offer insufficient protection against SARS-CoV-2 variants from mink. Twit Text FOAVip SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33857422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33857422 #FOAvip English Wikipedia <ref>{{Cite pmid|33857422}}</ref> SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization #MMPMID33857422 Hoffmann M; Zhang L; Kruger N; Graichen L; Kleine-Weber H; Hofmann-Winkler H; Kempf A; Nessler S; Riggert J; Winkler MS; Schulz S; Jack HM; Pohlmann S Cell Rep 2021[Apr]; 35 (3): 109017 PMID33857422show ga Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to farmed mink has been observed in Europe and the US. In the infected animals, viral variants arose that harbored mutations in the spike (S) protein, the target of neutralizing antibodies, and these variants were transmitted back to humans. This raised concerns that mink might become a constant source of human infection with SARS-CoV-2 variants associated with an increased threat to human health and resulted in mass culling of mink. Here, we report that mutations frequently found in the S proteins of SARS-CoV-2 from mink are mostly compatible with efficient entry into human cells and its inhibition by soluble angiotensin-converting enzyme 2 (ACE2). In contrast, mutation Y453F reduces neutralization by an antibody with emergency use authorization for coronavirus disease 2019 (COVID-19) therapy and sera/plasma from COVID-19 patients. These results suggest that antibody responses induced upon infection or certain antibodies used for treatment might offer insufficient protection against SARS-CoV-2 variants from mink. |*COVID-19/genetics/immunology[MESH] |*Mink/immunology/virology[MESH] |*SARS-CoV-2/genetics/immunology[MESH] |*Spike Glycoprotein, Coronavirus/genetics/immunology[MESH] |A549 Cells[MESH] |Angiotensin-Converting Enzyme 2/immunology[MESH] |Animals[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |Chlorocebus aethiops[MESH] |Cricetinae[MESH] |Humans[MESH]SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutral(epmc).pdf DeepDyve Pubget Overpricing