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10.1016/S1473-3099(21)00170-5 http://scihub22266oqcxt.onion/10.1016/S1473-3099(21)00170-5 33857406!8041359!33857406     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33857406&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet+Infect+Dis 2021 ; 21 (9): 1246-1256 Nephropedia Template TP {{tp|p=33857406|t=2021. Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B 1 1 7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study |pdf=|usr=}}{{33857406}} gab.com Text Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B 1 1 7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study JO: Lancet Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33857406 #FOAvip BACKGROUND: Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of the B.1.1.7 variant of concern (VOC), including virological characteristics and clinical severity in contemporaneous patients with and without the variant. METHODS: In this cohort study, samples positive for SARS-CoV-2 on PCR that were collected from Nov 9, 2020, for patients acutely admitted to one of two hospitals on or before Dec 20, 2020, in London, UK, were sequenced and analysed for the presence of VOC-defining mutations. We fitted Poisson regression models to investigate the association between B.1.1.7 infection and severe disease (defined as point 6 or higher on the WHO ordinal scale within 14 days of symptoms or positive test) and death within 28 days of a positive test and did supplementary genomic analyses in a cohort of chronically shedding patients and in a cohort of remdesivir-treated patients. Viral load was compared by proxy, using PCR cycle threshold values and sequencing read depths. FINDINGS: Of 496 patients with samples positive for SARS-CoV-2 on PCR and who met inclusion criteria, 341 had samples that could be sequenced. 198 (58%) of 341 had B.1.1.7 infection and 143 (42%) had non-B.1.1.7 infection. We found no evidence of an association between severe disease and death and lineage (B.1.1.7 vs non-B.1.1.7) in unadjusted analyses (prevalence ratio [PR] 0.97 [95% CI 0.72-1.31]), or in analyses adjusted for hospital, sex, age, comorbidities, and ethnicity (adjusted PR 1.02 [0.76-1.38]). We detected no B.1.1.7 VOC-defining mutations in 123 chronically shedding immunocompromised patients or in 32 remdesivir-treated patients. Viral load by proxy was higher in B.1.1.7 samples than in non-B.1.1.7 samples, as measured by cycle threshold value (mean 28.8 [SD 4.7] vs 32.0 [4.8]; p=0.0085) and genomic read depth (1280 [1004] vs 831 [682]; p=0.0011). INTERPRETATION: Emerging evidence exists of increased transmissibility of B.1.1.7, and we found increased virus load by proxy for B.1.1.7 in our data. We did not identify an association of the variant with severe disease in this hospitalised cohort. FUNDING: University College London Hospitals NHS Trust, University College London/University College London Hospitals NIHR Biomedical Research Centre, Engineering and Physical Sciences Research Council. Twit Text FOAVip Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B 1 1 7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study ????Lancet Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33857406 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33857406 #FOAvip English Wikipedia <ref>{{Cite pmid|33857406}}</ref> Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B 1 1 7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study #MMPMID33857406 Frampton D; Rampling T; Cross A; Bailey H; Heaney J; Byott M; Scott R; Sconza R; Price J; Margaritis M; Bergstrom M; Spyer MJ; Miralhes PB; Grant P; Kirk S; Valerio C; Mangera Z; Prabhahar T; Moreno-Cuesta J; Arulkumaran N; Singer M; Shin GY; Sanchez E; Paraskevopoulou SM; Pillay D; McKendry RA; Mirfenderesky M; Houlihan CF; Nastouli E Lancet Infect Dis 2021[Sep]; 21 (9): 1246-1256 PMID33857406show ga BACKGROUND: Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of the B.1.1.7 variant of concern (VOC), including virological characteristics and clinical severity in contemporaneous patients with and without the variant. METHODS: In this cohort study, samples positive for SARS-CoV-2 on PCR that were collected from Nov 9, 2020, for patients acutely admitted to one of two hospitals on or before Dec 20, 2020, in London, UK, were sequenced and analysed for the presence of VOC-defining mutations. We fitted Poisson regression models to investigate the association between B.1.1.7 infection and severe disease (defined as point 6 or higher on the WHO ordinal scale within 14 days of symptoms or positive test) and death within 28 days of a positive test and did supplementary genomic analyses in a cohort of chronically shedding patients and in a cohort of remdesivir-treated patients. Viral load was compared by proxy, using PCR cycle threshold values and sequencing read depths. FINDINGS: Of 496 patients with samples positive for SARS-CoV-2 on PCR and who met inclusion criteria, 341 had samples that could be sequenced. 198 (58%) of 341 had B.1.1.7 infection and 143 (42%) had non-B.1.1.7 infection. We found no evidence of an association between severe disease and death and lineage (B.1.1.7 vs non-B.1.1.7) in unadjusted analyses (prevalence ratio [PR] 0.97 [95% CI 0.72-1.31]), or in analyses adjusted for hospital, sex, age, comorbidities, and ethnicity (adjusted PR 1.02 [0.76-1.38]). We detected no B.1.1.7 VOC-defining mutations in 123 chronically shedding immunocompromised patients or in 32 remdesivir-treated patients. Viral load by proxy was higher in B.1.1.7 samples than in non-B.1.1.7 samples, as measured by cycle threshold value (mean 28.8 [SD 4.7] vs 32.0 [4.8]; p=0.0085) and genomic read depth (1280 [1004] vs 831 [682]; p=0.0011). INTERPRETATION: Emerging evidence exists of increased transmissibility of B.1.1.7, and we found increased virus load by proxy for B.1.1.7 in our data. We did not identify an association of the variant with severe disease in this hospitalised cohort. FUNDING: University College London Hospitals NHS Trust, University College London/University College London Hospitals NIHR Biomedical Research Centre, Engineering and Physical Sciences Research Council. |*Genome, Viral[MESH] |*Severity of Illness Index[MESH] |*Whole Genome Sequencing[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*virology[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |London[MESH] |Male[MESH] |Middle Aged[MESH] |Phylogeny[MESH] |SARS-CoV-2/*genetics[MESH] |United Kingdom[MESH] |Viral Load[MESH]Genomic characteristics and clinical effect of the emergent SARS-CoV-2(epmc).pdf DeepDyve Pubget Overpricing