Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1080/14728222.2021.1918103 http://scihub22266oqcxt.onion/10.1080/14728222.2021.1918103 33857397!8095161!33857397     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Expert+Opin+Ther+Targets 2021 ; 25 (6): 491-508 Nephropedia Template TP {{tp|p=33857397|t=2021. TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2 |pdf=|usr=}}{{33857397}} gab.com Text TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2 JO: Expert Opin Ther Targets http://www.kidney.de/pget.php?&tw=1&pmid=33857397 #FOAvip Introduction: The COVID-19 pandemic remains aglobal challenge. While there are mRNA agents on the horizon as apotential prevention, adefinitive drug therapy is an unmet medical need. The hyperinflammatory response, known as the 'cytokine storm', is chiefly responsible for complications and deaths. The binding of spike-glycoprotein of SARS-CoV-2 to TLR4 receptors has been documented in several studies and has been found to play arole in hyperinflammation; hence, there is an interest in TLR4 as apotential drug target.Areas covered: This review discusses the neurological and respiratory complications of SARS-CoV-2 infection and progresses to examine the role of the 'cytokine storm' and the involvement of TLR4 receptors in these complications. The possibility of using TLR4 modulators to curb the complications are considered and finally, ashort perspective on future potential drug treatments is offered. Various databases were searched including Pub-Med, Google Scholar, and Medline. The search mainly included research articles, meta-analysis, retrospective studies, reports, and systematic reviews.Expert opinion: TLR4 modulators are being investigated in clinical trials for COVID-19. Challenges in terms of structural diversity of the agents, their natural origin, and efficacy demand extensive research. Twit Text FOAVip TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2 ????Expert Opin Ther Targets http://www.kidney.de/pget.php?&tw=1&pmid=33857397 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33857397 #FOAvip English Wikipedia <ref>{{Cite pmid|33857397}}</ref> TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2 #MMPMID33857397 Kaushik D; Bhandari R; Kuhad A Expert Opin Ther Targets 2021[Jun]; 25 (6): 491-508 PMID33857397show ga Introduction: The COVID-19 pandemic remains aglobal challenge. While there are mRNA agents on the horizon as apotential prevention, adefinitive drug therapy is an unmet medical need. The hyperinflammatory response, known as the 'cytokine storm', is chiefly responsible for complications and deaths. The binding of spike-glycoprotein of SARS-CoV-2 to TLR4 receptors has been documented in several studies and has been found to play arole in hyperinflammation; hence, there is an interest in TLR4 as apotential drug target.Areas covered: This review discusses the neurological and respiratory complications of SARS-CoV-2 infection and progresses to examine the role of the 'cytokine storm' and the involvement of TLR4 receptors in these complications. The possibility of using TLR4 modulators to curb the complications are considered and finally, ashort perspective on future potential drug treatments is offered. Various databases were searched including Pub-Med, Google Scholar, and Medline. The search mainly included research articles, meta-analysis, retrospective studies, reports, and systematic reviews.Expert opinion: TLR4 modulators are being investigated in clinical trials for COVID-19. Challenges in terms of structural diversity of the agents, their natural origin, and efficacy demand extensive research. |*COVID-19 Drug Treatment[MESH] |Animals[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |COVID-19/complications[MESH] |Humans[MESH] |Lung Diseases/*complications[MESH] |Nervous System Diseases/*complications[MESH] |Retrospective Studies[MESH] |SARS-CoV-2/isolation & purification[MESH]TLR4 as a therapeutic target for respiratory and neurological complica(epmc).pdf DeepDyve Pubget Overpricing