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10.1002/bies.202000312 http://scihub22266oqcxt.onion/10.1002/bies.202000312 33857328!8250295!33857328     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioessays 2021 ; 43 (6): e2000312 Nephropedia Template TP {{tp|p=33857328|t=2021. Can ketone bodies inactivate coronavirus spike protein? The potential of biocidal agents against SARS-CoV-2 |pdf=|usr=}}{{33857328}} gab.com Text Can ketone bodies inactivate coronavirus spike protein The potential of biocidal agents against SARS-CoV-2 JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=33857328 #FOAvip Biocidal agents such as formaldehyde and glutaraldehyde are able to inactivate several coronaviruses including SARS-CoV-2. In this article, an insight into one mechanism for the inactivation of these viruses by those two agents is presented, based on analysis of previous observations during electron microscopic examination of several members of the orthocoronavirinae subfamily, including the new virus SARS-CoV-2. This inactivation is proposed to occur through Schiff base reaction-induced conformational changes in the spike glycoprotein leading to its disruption or breakage, which can prevent binding of the virus to cellular receptors. Also, a new prophylactic and therapeutic measure against SARS-CoV-2 using acetoacetate is proposed, suggesting that it could similarly break the viral spike through Schiff base reaction with lysines of the spike protein. This measure needs to be confirmed experimentally before consideration. In addition, a new line of research is proposed to help find a broad-spectrum antivirus against several members of this subfamily. Twit Text FOAVip Can ketone bodies inactivate coronavirus spike protein The potential of biocidal agents against SARS-CoV-2 ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=33857328 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33857328 #FOAvip English Wikipedia <ref>{{Cite pmid|33857328}}</ref> Can ketone bodies inactivate coronavirus spike protein? The potential of biocidal agents against SARS-CoV-2 #MMPMID33857328 Shaheen A Bioessays 2021[Jun]; 43 (6): e2000312 PMID33857328show ga Biocidal agents such as formaldehyde and glutaraldehyde are able to inactivate several coronaviruses including SARS-CoV-2. In this article, an insight into one mechanism for the inactivation of these viruses by those two agents is presented, based on analysis of previous observations during electron microscopic examination of several members of the orthocoronavirinae subfamily, including the new virus SARS-CoV-2. This inactivation is proposed to occur through Schiff base reaction-induced conformational changes in the spike glycoprotein leading to its disruption or breakage, which can prevent binding of the virus to cellular receptors. Also, a new prophylactic and therapeutic measure against SARS-CoV-2 using acetoacetate is proposed, suggesting that it could similarly break the viral spike through Schiff base reaction with lysines of the spike protein. This measure needs to be confirmed experimentally before consideration. In addition, a new line of research is proposed to help find a broad-spectrum antivirus against several members of this subfamily. |Animals[MESH] |Antiviral Agents/chemistry/pharmacology[MESH] |Disinfectants/chemistry/*pharmacology[MESH] |Formaldehyde/chemistry/pharmacology[MESH] |Glutaral/chemistry/pharmacology[MESH] |Humans[MESH] |Ketone Bodies/chemistry/metabolism/*pharmacology[MESH] |Ketosis/etiology/virology[MESH] |SARS-CoV-2/*drug effects/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/*metabolism[MESH]Can ketone bodies inactivate coronavirus spike protein? The potential (epmc).pdf DeepDyve Pubget Overpricing