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10.1515/cclm-2021-0313 http://scihub22266oqcxt.onion/10.1515/cclm-2021-0313 33855843!ä!33855843 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Chem+Lab+Med 2021 ; 59 (8): 1444-1452 Nephropedia Template TP {{tp|p=33855843|t=2021. Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers |pdf=|usr=}}{{33855843}} gab.com Text Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers JO: Clin Chem Lab Med http://www.kidney.de/pget.php?&tw=1&pmid=33855843 #FOAvip OBJECTIVES: SARS-CoV-2 serology presents an important role in several aspects of COVID-19 pandemic. Immunoassays performances have to be accurately evaluated and correlated with neutralizing antibodies. We investigated the analytical and clinical performances of a SARS-CoV-2 RBD IgG assay, automated on a high throughput platform, and the correlation of the antibodies (Ab) levels with the plaque reduction neutralization (PRNT(50)) Ab titers. METHODS: A series of 546 samples were evaluated by SARS-CoV-2 RBD IgG assay (Snibe diagnostics), including 171 negative and 168 positive SARS-CoV-2 subjects and a further group of 207 subjects of the COVID-19 family clusters follow-up cohort. RESULTS: Assay imprecision ranged from 3.98 to 12.18% being satisfactory at low and medium levels; linearity was excellent in all the measurement range. Considering specimens collected after 14 days post symptoms onset, overall sensitivity and specificity were 99.0 and 92.5%, respectively. A total of 281 leftover samples results of the PRNT(50) test were available. An elevated correlation was obtained between the SARS-CoV-2 RBD IgG assay and the PRNT(50) titer at univariate (rho=0.689) and multivariate (rho=0.712) analyses. CONCLUSIONS: SARS-CoV-2 S-RBD IgG assay shows satisfactory analytical and clinical performances, and a strong correlation with sera neutralizing activity. Twit Text FOAVip Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers ????Clin Chem Lab Med http://www.kidney.de/pget.php?&tw=1&pmid=33855843 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33855843 #FOAvip English Wikipedia <ref>{{Cite pmid|33855843}}</ref> Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers #MMPMID33855843 Padoan A; Bonfante F; Cosma C; Di Chiara C; Sciacovelli L; Pagliari M; Bortolami A; Costenaro P; Musso G; Basso D; Giaquinto C; Plebani M Clin Chem Lab Med 2021[Jul]; 59 (8): 1444-1452 PMID33855843show ga OBJECTIVES: SARS-CoV-2 serology presents an important role in several aspects of COVID-19 pandemic. Immunoassays performances have to be accurately evaluated and correlated with neutralizing antibodies. We investigated the analytical and clinical performances of a SARS-CoV-2 RBD IgG assay, automated on a high throughput platform, and the correlation of the antibodies (Ab) levels with the plaque reduction neutralization (PRNT(50)) Ab titers. METHODS: A series of 546 samples were evaluated by SARS-CoV-2 RBD IgG assay (Snibe diagnostics), including 171 negative and 168 positive SARS-CoV-2 subjects and a further group of 207 subjects of the COVID-19 family clusters follow-up cohort. RESULTS: Assay imprecision ranged from 3.98 to 12.18% being satisfactory at low and medium levels; linearity was excellent in all the measurement range. Considering specimens collected after 14 days post symptoms onset, overall sensitivity and specificity were 99.0 and 92.5%, respectively. A total of 281 leftover samples results of the PRNT(50) test were available. An elevated correlation was obtained between the SARS-CoV-2 RBD IgG assay and the PRNT(50) titer at univariate (rho=0.689) and multivariate (rho=0.712) analyses. CONCLUSIONS: SARS-CoV-2 S-RBD IgG assay shows satisfactory analytical and clinical performances, and a strong correlation with sera neutralizing activity. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Neutralizing/blood/*immunology[MESH] |Antibodies, Viral/blood[MESH] |COVID-19/pathology/virology[MESH] |Child[MESH] |Female[MESH] |Humans[MESH] |Immunoassay/methods[MESH] |Immunoglobulin G/blood/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Neutralization Tests/*methods[MESH] |Protein Subunits/immunology[MESH] |SARS-CoV-2/isolation & purification/*metabolism[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH]Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: (epmc).pdf DeepDyve Pubget Overpricing