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10.3389/fcvm.2021.649922

http://scihub22266oqcxt.onion/10.3389/fcvm.2021.649922
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33855053!8039152!33855053
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suck abstract from ncbi


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pmid33855053      Front+Cardiovasc+Med 2021 ; 8 (ä): 649922
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  • Stroke in SARS-CoV-2 Infection: A Pictorial Overview of the Pathoetiology #MMPMID33855053
  • Aghayari Sheikh Neshin S; Shahjouei S; Koza E; Friedenberg I; Khodadadi F; Sabra M; Kobeissy F; Ansari S; Tsivgoulis G; Li J; Abedi V; Wolk DM; Zand R
  • Front Cardiovasc Med 2021[]; 8 (ä): 649922 PMID33855053show ga
  • Since the early days of the pandemic, there have been several reports of cerebrovascular complications during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Numerous studies proposed a role for SARS-CoV-2 in igniting stroke. In this review, we focused on the pathoetiology of stroke among the infected patients. We pictured the results of the SARS-CoV-2 invasion to the central nervous system (CNS) via neuronal and hematogenous routes, in addition to viral infection in peripheral tissues with extensive crosstalk with the CNS. SARS-CoV-2 infection results in pro-inflammatory cytokine and chemokine release and activation of the immune system, COVID-19-associated coagulopathy, endotheliitis and vasculitis, hypoxia, imbalance in the renin-angiotensin system, and cardiovascular complications that all may lead to the incidence of stroke. Critically ill patients, those with pre-existing comorbidities and patients taking certain medications, such as drugs with elevated risk for arrhythmia or thrombophilia, are more susceptible to a stroke after SARS-CoV-2 infection. By providing a pictorial narrative review, we illustrated these associations in detail to broaden the scope of our understanding of stroke in SARS-CoV-2-infected patients. We also discussed the role of antiplatelets and anticoagulants for stroke prevention and the need for a personalized approach among patients with SARS-CoV-2 infection.
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