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10.3389/fimmu.2021.645741 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.645741 33854510!8039457!33854510     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 645741 Nephropedia Template TP {{tp|p=33854510|t=2021. Commensal Microbiome Expands Tgammadelta17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia |pdf=|usr=}}{{33854510}} gab.com Text Commensal Microbiome Expands Tgammadelta17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33854510 #FOAvip Particulate matter (PM) induces neutrophilic inflammation and deteriorates the prognosis of diseases such as cardiovascular diseases, cancers, and infections, including COVID-19. Here, we addressed the role of gammadelta T cells and intestinal microbiome in PM-induced acute neutrophilia. gammadelta T cells are a heterogeneous population composed of Tgammadelta1, Tgammadelta2, Tgammadelta17, and naive gammadelta T cells (TgammadeltaN) and commensal bacteria promote local expansion of Tgammadelta17 cells, particularly in the lung and gut without affecting their Vgamma repertoire. Tgammadelta17 cells are more tissue resident than Tgammadelta1 cells, while TgammadeltaN cells are circulating cells. IL-1R expression in Tgammadelta17 cells is highest in the lung and they outnumber all the other type 17 cells such as Th17, ILC3, NKT17, and MAIT17 cells. Upon PM exposure, IL-1beta-secreting neutrophils and IL-17-producing Tgammadelta17 cells attract each other around the airways. Accordingly, PM-induced neutrophilia was significantly relieved in gammadelta T- or IL-17-deficient and germ-free mice. Collectively, these findings show that the commensal microbiome promotes PM-induced neutrophilia in the lung via Tgammadelta17 cells. Twit Text FOAVip Commensal Microbiome Expands Tgammadelta17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33854510 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33854510 #FOAvip English Wikipedia <ref>{{Cite pmid|33854510}}</ref> Commensal Microbiome Expands Tgammadelta17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia #MMPMID33854510 Yang C; Kwon DI; Kim M; Im SH; Lee YJ Front Immunol 2021[]; 12 (ä): 645741 PMID33854510show ga Particulate matter (PM) induces neutrophilic inflammation and deteriorates the prognosis of diseases such as cardiovascular diseases, cancers, and infections, including COVID-19. Here, we addressed the role of gammadelta T cells and intestinal microbiome in PM-induced acute neutrophilia. gammadelta T cells are a heterogeneous population composed of Tgammadelta1, Tgammadelta2, Tgammadelta17, and naive gammadelta T cells (TgammadeltaN) and commensal bacteria promote local expansion of Tgammadelta17 cells, particularly in the lung and gut without affecting their Vgamma repertoire. Tgammadelta17 cells are more tissue resident than Tgammadelta1 cells, while TgammadeltaN cells are circulating cells. IL-1R expression in Tgammadelta17 cells is highest in the lung and they outnumber all the other type 17 cells such as Th17, ILC3, NKT17, and MAIT17 cells. Upon PM exposure, IL-1beta-secreting neutrophils and IL-17-producing Tgammadelta17 cells attract each other around the airways. Accordingly, PM-induced neutrophilia was significantly relieved in gammadelta T- or IL-17-deficient and germ-free mice. Collectively, these findings show that the commensal microbiome promotes PM-induced neutrophilia in the lung via Tgammadelta17 cells. |*Microbiota[MESH] |Animals[MESH] |Asthma/etiology/metabolism/pathology[MESH] |Biomarkers[MESH] |Cytokines/metabolism[MESH] |Disease Models, Animal[MESH] |Disease Susceptibility[MESH] |Fluorescent Antibody Technique[MESH] |Immunity, Innate[MESH] |Immunophenotyping[MESH] |Leukocytosis/*etiology/metabolism/pathology[MESH] |Lung/*immunology/metabolism/pathology[MESH] |Mice[MESH] |Neutrophils/metabolism/*pathology[MESH] |Particulate Matter/*adverse effects[MESH] |Receptors, Antigen, T-Cell, gamma-delta/*metabolism[MESH] |T-Lymphocyte Subsets/immunology/metabolism[MESH]Commensal Microbiome Expands Tgammadelta17 Cells in the Lung and Promo(epmc).pdf DeepDyve Pubget Overpricing