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10.1126/science.abh2644 http://scihub22266oqcxt.onion/10.1126/science.abh2644 33853970!8139423!33853970     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 372 (6544): 815-821 Nephropedia Template TP {{tp|p=33853970|t=2021. Genomics and epidemiology of the P 1 SARS-CoV-2 lineage in Manaus, Brazil |pdf=|usr=}}{{33853970}} gab.com Text Genomics and epidemiology of the P 1 SARS-CoV-2 lineage in Manaus, Brazil JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=33853970 #FOAvip Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in the spike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2 (angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% of the protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness. Twit Text FOAVip Genomics and epidemiology of the P 1 SARS-CoV-2 lineage in Manaus, Brazil ????Science http://www.kidney.de/pget.php?&tw=1&pmid=33853970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33853970 #FOAvip English Wikipedia <ref>{{Cite pmid|33853970}}</ref> Genomics and epidemiology of the P 1 SARS-CoV-2 lineage in Manaus, Brazil #MMPMID33853970 Faria NR; Mellan TA; Whittaker C; Claro IM; Candido DDS; Mishra S; Crispim MAE; Sales FCS; Hawryluk I; McCrone JT; Hulswit RJG; Franco LAM; Ramundo MS; de Jesus JG; Andrade PS; Coletti TM; Ferreira GM; Silva CAM; Manuli ER; Pereira RHM; Peixoto PS; Kraemer MUG; Gaburo N Jr; Camilo CDC; Hoeltgebaum H; Souza WM; Rocha EC; de Souza LM; de Pinho MC; Araujo LJT; Malta FSV; de Lima AB; Silva JDP; Zauli DAG; Ferreira ACS; Schnekenberg RP; Laydon DJ; Walker PGT; Schluter HM; Dos Santos ALP; Vidal MS; Del Caro VS; Filho RMF; Dos Santos HM; Aguiar RS; Proenca-Modena JL; Nelson B; Hay JA; Monod M; Miscouridou X; Coupland H; Sonabend R; Vollmer M; Gandy A; Prete CA Jr; Nascimento VH; Suchard MA; Bowden TA; Pond SLK; Wu CH; Ratmann O; Ferguson NM; Dye C; Loman NJ; Lemey P; Rambaut A; Fraiji NA; Carvalho MDPSS; Pybus OG; Flaxman S; Bhatt S; Sabino EC Science 2021[May]; 372 (6544): 815-821 PMID33853970show ga Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in the spike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2 (angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergence occurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% of the protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced global genomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immune evasion, is critical to accelerate pandemic responsiveness. |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Brazil/epidemiology[MESH] |COVID-19/*epidemiology/*virology[MESH] |Communicable Diseases, Emerging/*epidemiology/*virology[MESH] |Epidemiological Monitoring[MESH] |Genome, Viral[MESH] |Genomics[MESH] |Humans[MESH] |Models, Theoretical[MESH] |Molecular Epidemiology[MESH] |Mutation[MESH] |Protein Binding[MESH] |SARS-CoV-2/*classification/*genetics/isolation & purification[MESH] |Spike Glycoprotein, Coronavirus/*genetics/metabolism[MESH]Genomics and epidemiology of the P 1 SARS-CoV-2 lineage in Manaus, Bra(epmc).pdf DeepDyve Pubget Overpricing