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10.1371/journal.pone.0250158 http://scihub22266oqcxt.onion/10.1371/journal.pone.0250158 33852639!8046346!33852639     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (4): e0250158 Nephropedia Template TP {{tp|p=33852639|t=2021. Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study |pdf=|usr=}}{{33852639}} gab.com Text Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33852639 #FOAvip While the world awaits a widely available COVID-19 vaccine, availability of testing is limited in many regions and can be further compounded by shortages of reagents, prolonged processing time and delayed results. One approach to rapid testing is to leverage the volatile organic compound (VOC) signature of SARS-CoV-2 infection. Detection dogs, a biological sensor of VOCs, were utilized to investigate whether SARS-CoV-2 positive urine and saliva patient samples had a unique odor signature. The virus was inactivated in all training samples with either detergent or heat treatment. Using detergent-inactivated urine samples, dogs were initially trained to find samples collected from hospitalized patients confirmed with SARS-CoV-2 infection, while ignoring samples collected from controls. Dogs were then tested on their ability to spontaneously recognize heat-treated urine samples as well as heat-treated saliva from hospitalized SARS-CoV-2 positive patients. Dogs successfully discriminated between infected and uninfected urine samples, regardless of the inactivation protocol, as well as heat-treated saliva samples. Generalization to novel samples was limited, particularly after intensive training with a restricted sample set. A unique odor associated with SARS-CoV-2 infection present in human urine as well as saliva, provides impetus for the development of odor-based screening, either by electronic, chemical, or biological sensing methods. The use of dogs for screening in an operational setting will require training with a large number of novel SARS-CoV-2 positive and confirmed negative samples. Twit Text FOAVip Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33852639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33852639 #FOAvip English Wikipedia <ref>{{Cite pmid|33852639}}</ref> Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study #MMPMID33852639 Essler JL; Kane SA; Nolan P; Akaho EH; Berna AZ; DeAngelo A; Berk RA; Kaynaroglu P; Plymouth VL; Frank ID; Weiss SR; Odom John AR; Otto CM PLoS One 2021[]; 16 (4): e0250158 PMID33852639show ga While the world awaits a widely available COVID-19 vaccine, availability of testing is limited in many regions and can be further compounded by shortages of reagents, prolonged processing time and delayed results. One approach to rapid testing is to leverage the volatile organic compound (VOC) signature of SARS-CoV-2 infection. Detection dogs, a biological sensor of VOCs, were utilized to investigate whether SARS-CoV-2 positive urine and saliva patient samples had a unique odor signature. The virus was inactivated in all training samples with either detergent or heat treatment. Using detergent-inactivated urine samples, dogs were initially trained to find samples collected from hospitalized patients confirmed with SARS-CoV-2 infection, while ignoring samples collected from controls. Dogs were then tested on their ability to spontaneously recognize heat-treated urine samples as well as heat-treated saliva from hospitalized SARS-CoV-2 positive patients. Dogs successfully discriminated between infected and uninfected urine samples, regardless of the inactivation protocol, as well as heat-treated saliva samples. Generalization to novel samples was limited, particularly after intensive training with a restricted sample set. A unique odor associated with SARS-CoV-2 infection present in human urine as well as saliva, provides impetus for the development of odor-based screening, either by electronic, chemical, or biological sensing methods. The use of dogs for screening in an operational setting will require training with a large number of novel SARS-CoV-2 positive and confirmed negative samples. |Animals[MESH] |COVID-19 Testing/*methods[MESH] |COVID-19/*diagnosis/urine[MESH] |Dogs[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Mass Screening[MESH] |Proof of Concept Study[MESH] |SARS-CoV-2/isolation & purification[MESH] |Saliva/chemistry[MESH] |Specimen Handling/methods[MESH] |Volatile Organic Compounds/chemistry[MESH]Discrimination of SARS-CoV-2 infected patient samples by detection dog(epmc).pdf DeepDyve Pubget Overpricing