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10.1016/j.sjbs.2021.03.074

http://scihub22266oqcxt.onion/10.1016/j.sjbs.2021.03.074
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33850424!8032480!33850424
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suck abstract from ncbi


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pmid33850424      Saudi+J+Biol+Sci 2021 ; 28 (7): 3926-3928
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  • Virus-receptor interactions of SARS-CoV-2 spikereceptor-binding domain and human neuropilin-1 b1 domain #MMPMID33850424
  • Alnomasy SF
  • Saudi J Biol Sci 2021[Jul]; 28 (7): 3926-3928 PMID33850424show ga
  • In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wahan, China and it causes disease which is known as COVID-19. This infection spreads everywhere in the world, and it leads to an enormous number of death among individuals. The mystery issue about SARS-CoV-2 that appears not to have functions of a hemagglutinin and neuraminidase like other coronaviruses. Angiotensin-converting enzyme 2 (ACE2) is the main surface receptor for entering SARS-CoV-2 into the host cell. This entry process is mediated by binding the SARS-CoV-2 spike receptor-binding domain (RBD) to ACE2. Recently, researchers discover a new receptor responsible for the SARS-CoV-2 entry which is neuropilin-1 (NRP1). So, this work provides afford a knowledge of how the initial interaction between SARS-CoV-2 spike RBD and NRP1 b1 domain may occur. Understanding this interaction would be very necessary for drug design against SARS-CoV-2.
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