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10.1038/s41577-021-00553-8

http://scihub22266oqcxt.onion/10.1038/s41577-021-00553-8
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33850327!8043092!33850327
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suck abstract from ncbi

pmid33850327      Nat+Rev+Immunol 2021 ; 21 (6): 337-339
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  • Is IL-6 a key cytokine target for therapy in COVID-19? #MMPMID33850327
  • Jones SA; Hunter CA
  • Nat Rev Immunol 2021[Jun]; 21 (6): 337-339 PMID33850327show ga
  • The identification of elevated IL-6 levels in patients with severe COVID-19 led to the rapid development of clinical trials targeting this cytokine. Overall, these trials do not support the widespread use of IL-6 antagonists in hospitalized patients with mild-to-moderate disease, but IL-6 antagonists may be beneficial when rapidly deployed in patients with severe COVID-19, as we discuss here.
  • |*COVID-19 Drug Treatment[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antibodies, Monoclonal, Humanized/adverse effects/therapeutic use[MESH]
  • |COVID-19/complications/*immunology[MESH]
  • |Cytokine Release Syndrome/*drug therapy/etiology/*immunology[MESH]
  • |Cytokines/antagonists & inhibitors[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*antagonists & inhibitors/blood[MESH]
  • |Receptors, Interleukin-6/antagonists & inhibitors[MESH]
  • |Severity of Illness Index[MESH]


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