Is IL-6 a key cytokine target for therapy in COVID-19? #MMPMID33850327
Jones SA; Hunter CA
Nat Rev Immunol 2021[Jun]; 21 (6): 337-339 PMID33850327show ga
The identification of elevated IL-6 levels in patients with severe COVID-19 led to the rapid development of clinical trials targeting this cytokine. Overall, these trials do not support the widespread use of IL-6 antagonists in hospitalized patients with mild-to-moderate disease, but IL-6 antagonists may be beneficial when rapidly deployed in patients with severe COVID-19, as we discuss here.