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10.1038/s41598-021-87511-5 http://scihub22266oqcxt.onion/10.1038/s41598-021-87511-5 33850241!8044086!33850241     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 8017 Nephropedia Template TP {{tp|p=33850241|t=2021. Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers |pdf=|usr=}}{{33850241}} gab.com Text Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33850241 #FOAvip Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl) amino]pentyl](ethyl) amino]-ethanol, HCQ), an effective anti-malarial drug, has been tested in the clinics for potential treatment of severe coronavirus disease 2019 (COVID-19). Despite the controversy around the clinical benefits of HCQ, the existence of a chiral center in the molecule to possess two optical isomers suggests that there might be an enantiomeric difference on the treatment of COVID-19. Due to their poor resolution and the inability of quantification by previously reported methods for the analysis of HCQ enantiomers, it is necessary to develop an analytical method to achieve baseline separation for quantitative and accurate determination of the enantiomeric purity in order to compare the efficacy and toxicity profiles of different enantiomers. In this study, we developed and validated an accurate and reproducible normal phase chiral high-performance liquid chromatography (HPLC) method for the analysis of two enantiomers of HCQ, and the method was further evaluated with biological samples. With this newly developed method, the relative standard deviations of all analytes were lower than 5%, and the limits of quantification were 0.27 mug/ml, 0.34 mug/ml and 0.20 mug/ml for racemate, R- and S-enantiomer, respectively. The present method provides an essential analytical tool for preclinical and clinical evaluation of HCQ enantiomers for potential treatment of COVID-19. Twit Text FOAVip Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33850241 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33850241 #FOAvip English Wikipedia <ref>{{Cite pmid|33850241}}</ref> Development of a chiral HPLC method for the separation and quantification of hydroxychloroquine enantiomers #MMPMID33850241 Xiong X; Wang K; Tang T; Fang J; Chen Y Sci Rep 2021[Apr]; 11 (1): 8017 PMID33850241show ga Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl) amino]pentyl](ethyl) amino]-ethanol, HCQ), an effective anti-malarial drug, has been tested in the clinics for potential treatment of severe coronavirus disease 2019 (COVID-19). Despite the controversy around the clinical benefits of HCQ, the existence of a chiral center in the molecule to possess two optical isomers suggests that there might be an enantiomeric difference on the treatment of COVID-19. Due to their poor resolution and the inability of quantification by previously reported methods for the analysis of HCQ enantiomers, it is necessary to develop an analytical method to achieve baseline separation for quantitative and accurate determination of the enantiomeric purity in order to compare the efficacy and toxicity profiles of different enantiomers. In this study, we developed and validated an accurate and reproducible normal phase chiral high-performance liquid chromatography (HPLC) method for the analysis of two enantiomers of HCQ, and the method was further evaluated with biological samples. With this newly developed method, the relative standard deviations of all analytes were lower than 5%, and the limits of quantification were 0.27 mug/ml, 0.34 mug/ml and 0.20 mug/ml for racemate, R- and S-enantiomer, respectively. The present method provides an essential analytical tool for preclinical and clinical evaluation of HCQ enantiomers for potential treatment of COVID-19. |*Chromatography, High Pressure Liquid[MESH] |Animals[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/virology[MESH] |Humans[MESH] |Hydroxychloroquine/*analysis/blood/chemistry[MESH] |Rats[MESH] |Rats, Sprague-Dawley[MESH] |Reproducibility of Results[MESH] |SARS-CoV-2/isolation & purification[MESH]Development of a chiral HPLC method for the separation and quantificat(epmc).pdf DeepDyve Pubget Overpricing