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10.1038/s41421-021-00258-1 http://scihub22266oqcxt.onion/10.1038/s41421-021-00258-1 33850112!8043100!33850112     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Discov 2021 ; 7 (1): 24 Nephropedia Template TP {{tp|p=33850112|t=2021. Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages |pdf=|usr=}}{{33850112}} gab.com Text Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages JO: Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=33850112 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the alveoli, where abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion remains elusive. Here, we show that classically activated M1 AMs facilitate viral spread; however, alternatively activated M2 AMs limit the spread. M1 AMs utilize cellular softness to efficiently take up SARS-CoV-2. Subsequently, the invaded viruses take over the endo-lysosomal system to escape. M1 AMs have a lower endosomal pH, favoring membrane fusion and allowing the entry of viral RNA from the endosomes into the cytoplasm, where the virus achieves replication and is packaged to be released. In contrast, M2 AMs have a higher endosomal pH but a lower lysosomal pH, thus delivering the virus to lysosomes for degradation. In hACE2 transgenic mouse model, M1 AMs are found to facilitate SARS-CoV-2 infection of the lungs. These findings provide insights into the complex roles of AMs during SARS-CoV-2 infection, along with potential therapeutic targets. Twit Text FOAVip Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages ????Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=33850112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33850112 #FOAvip English Wikipedia <ref>{{Cite pmid|33850112}}</ref> Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages #MMPMID33850112 Lv J; Wang Z; Qu Y; Zhu H; Zhu Q; Tong W; Bao L; Lv Q; Cong J; Li D; Deng W; Yu P; Song J; Tong WM; Liu J; Liu Y; Qin C; Huang B Cell Discov 2021[Apr]; 7 (1): 24 PMID33850112show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the alveoli, where abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion remains elusive. Here, we show that classically activated M1 AMs facilitate viral spread; however, alternatively activated M2 AMs limit the spread. M1 AMs utilize cellular softness to efficiently take up SARS-CoV-2. Subsequently, the invaded viruses take over the endo-lysosomal system to escape. M1 AMs have a lower endosomal pH, favoring membrane fusion and allowing the entry of viral RNA from the endosomes into the cytoplasm, where the virus achieves replication and is packaged to be released. In contrast, M2 AMs have a higher endosomal pH but a lower lysosomal pH, thus delivering the virus to lysosomes for degradation. In hACE2 transgenic mouse model, M1 AMs are found to facilitate SARS-CoV-2 infection of the lungs. These findings provide insights into the complex roles of AMs during SARS-CoV-2 infection, along with potential therapeutic targets. äDistinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2(epmc).pdf DeepDyve Pubget Overpricing