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10.1007/s11906-021-01138-5

http://scihub22266oqcxt.onion/10.1007/s11906-021-01138-5
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33847825!8042355!33847825
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suck abstract from ncbi


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pmid33847825      Curr+Hypertens+Rep 2021 ; 23 (4): 20
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  • The Involvement of MicroRNAs in SARS-CoV-2 Infection Comorbid with HIV-Associated Preeclampsia #MMPMID33847825
  • Abel T; Moodley J; Naicker T
  • Curr Hypertens Rep 2021[Apr]; 23 (4): 20 PMID33847825show ga
  • PURPOSE OF REVIEW: This review investigated the potential role of microRNAs (miRNAs) in the synergy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, preeclampsia (PE), and human immunodeficiency virus (HIV) infection. Maternal health is a great concern when treating pregnant women fighting this triad of diseases, which is highly prevalent in South Africa. MicroRNAs are involved in fine-tuning of physiological processes. Disruptions to the balance of this minute protein can lead to various physiological changes that are sometimes pathological. RECENT FINDINGS: MicroRNAs have recently been implicated in PE and have been linked to the anti-angiogenic imbalance evident in PE. Recent in silico studies have identified potential host miRNAs with anti-viral properties against SARS-CoV-2 infection. Studies have demonstrated dysregulated expression of several miRNAs in HIV-1 infection along with the ability of HIV-1 to downregulate anti-viral host microRNAs. This review has highlighted the significant gap in literature on the potential of miRNAs in women with HIV-associated PE in synergy with the novel SARS-CoV-2 infection. In addition, this review has provided evidence of the critical role that the epigenetic regulatory mechanism of miRNA plays in viral infections and PE, thereby providing a foundation for further research investigating the potential of therapeutic miRNA development with fewer side-effects for pregnant women.
  • |*COVID-19[MESH]
  • |*HIV Infections/complications[MESH]
  • |*Hypertension[MESH]
  • |*MicroRNAs/genetics[MESH]
  • |*Pre-Eclampsia/genetics[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Pregnancy[MESH]


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