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10.1002/JLB.6COVCRA1120-762R http://scihub22266oqcxt.onion/10.1002/JLB.6COVCRA1120-762R 33847407!8250722!33847407     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Leukoc+Biol 2022 ; 111 (1): 283-289 Nephropedia Template TP {{tp|p=33847407|t=2022. TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID-19 patients |pdf=|usr=}}{{33847407}} gab.com Text TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID-19 patients JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=33847407 #FOAvip The potential protective or pathogenic role of the adaptive immune response to SARS-CoV-2 infection has been vigorously debated. While COVID-19 patients consistently generate a T lymphocyte response to SARS-CoV-2 antigens, evidence of significant immune dysregulation in these patients continues to accumulate. In this study, next generation sequencing of the T cell receptor beta chain (TRB) repertoire was conducted in hospitalized COVID-19 patients to determine if immunogenetic differences of the TRB repertoire contribute to disease course severity. Clustering of highly similar TRB CDR3 amino acid sequences across COVID-19 patients yielded 781 shared TRB sequences. The TRB sequences were then filtered for known associations with common diseases such as EBV and CMV. The remaining sequences were cross-referenced to a publicly accessible dataset that mapped COVID-19 specific TCRs to the SARS-CoV-2 genome. We identified 158 SARS-CoV-2 specific TRB sequences belonging to 134 clusters in our COVID-19 patients. Next, we investigated 113 SARS-CoV-2 specific clusters binding only one peptide target in relation to disease course. Distinct skewing of SARS-CoV-2 specific TRB sequences toward the nonstructural proteins (NSPs) encoded within ORF1a/b of the SARS-CoV-2 genome was observed in clusters associated with critical disease course when compared to COVID-19 clusters associated with a severe disease course. These data imply that T-lymphocyte reactivity towards peptides from NSPs of SARS-CoV-2 may not constitute an effective adaptive immune response and thus may negatively affect disease severity. Twit Text FOAVip TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID-19 patients ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=33847407 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33847407 #FOAvip English Wikipedia <ref>{{Cite pmid|33847407}}</ref> TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID-19 patients #MMPMID33847407 Assmann JLJC; Kolijn PM; Schrijver B; van Gammeren AJ; Loth DW; Ermens TAAM; Dik WA; van der Velden VHJ; Langerak AW J Leukoc Biol 2022[Jan]; 111 (1): 283-289 PMID33847407show ga The potential protective or pathogenic role of the adaptive immune response to SARS-CoV-2 infection has been vigorously debated. While COVID-19 patients consistently generate a T lymphocyte response to SARS-CoV-2 antigens, evidence of significant immune dysregulation in these patients continues to accumulate. In this study, next generation sequencing of the T cell receptor beta chain (TRB) repertoire was conducted in hospitalized COVID-19 patients to determine if immunogenetic differences of the TRB repertoire contribute to disease course severity. Clustering of highly similar TRB CDR3 amino acid sequences across COVID-19 patients yielded 781 shared TRB sequences. The TRB sequences were then filtered for known associations with common diseases such as EBV and CMV. The remaining sequences were cross-referenced to a publicly accessible dataset that mapped COVID-19 specific TCRs to the SARS-CoV-2 genome. We identified 158 SARS-CoV-2 specific TRB sequences belonging to 134 clusters in our COVID-19 patients. Next, we investigated 113 SARS-CoV-2 specific clusters binding only one peptide target in relation to disease course. Distinct skewing of SARS-CoV-2 specific TRB sequences toward the nonstructural proteins (NSPs) encoded within ORF1a/b of the SARS-CoV-2 genome was observed in clusters associated with critical disease course when compared to COVID-19 clusters associated with a severe disease course. These data imply that T-lymphocyte reactivity towards peptides from NSPs of SARS-CoV-2 may not constitute an effective adaptive immune response and thus may negatively affect disease severity. |*Hospitalization[MESH] |*Severity of Illness Index[MESH] |Aged[MESH] |Amino Acid Sequence[MESH] |COVID-19/*immunology/*pathology/virology[MESH] |Complementarity Determining Regions/immunology[MESH] |Genome, Viral[MESH] |Humans[MESH] |Polyproteins/chemistry/immunology/metabolism[MESH] |Receptors, Antigen, T-Cell, alpha-beta/*immunology[MESH] |SARS-CoV-2/genetics[MESH] |Time Factors[MESH]TRB sequences targeting ORF1a/b are associated with disease severity i(epmc).pdf DeepDyve Pubget Overpricing