Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1136/thoraxjnl-2020-216256 http://scihub22266oqcxt.onion/10.1136/thoraxjnl-2020-216256 33846275!8050882!33846275     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33846275&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thorax 2021 ; 76 (10): 1010-1019 Nephropedia Template TP {{tp|p=33846275|t=2021. Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19 |pdf=|usr=}}{{33846275}} gab.com Text Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19 JO: Thorax http://www.kidney.de/pget.php?&tw=1&pmid=33846275 #FOAvip BACKGROUND: Knowledge of the pathophysiology of COVID-19 is almost exclusively derived from studies that examined the immune response in blood. We here aimed to analyse the pulmonary immune response during severe COVID-19 and to compare this with blood responses. METHODS: This was an observational study in patients with COVID-19 admitted to the intensive care unit (ICU). Mononuclear cells were purified from bronchoalveolar lavage fluid (BALF) and blood, and analysed by spectral flow cytometry; inflammatory mediators were measured in BALF and plasma. FINDINGS: Paired blood and BALF samples were obtained from 17 patients, four of whom died in the ICU. Macrophages and T cells were the most abundant cells in BALF, with a high percentage of T cells expressing the ydelta T cell receptor. In the lungs, both CD4 and CD8 T cells were predominantly effector memory cells (87.3% and 83.8%, respectively), and these cells expressed higher levels of the exhaustion marker programmad death-1 than in peripheral blood. Prolonged ICU stay (>14 days) was associated with a reduced proportion of activated T cells in peripheral blood and even more so in BALF. T cell activation in blood, but not in BALF, was higher in fatal COVID-19 cases. Increased levels of inflammatory mediators were more pronounced in BALF than in plasma. INTERPRETATION: The bronchoalveolar immune response in COVID-19 has a unique local profile that strongly differs from the immune profile in peripheral blood. Fully elucidating COVID-19 pathophysiology will require investigation of the pulmonary immune response. Twit Text FOAVip Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19 ????Thorax http://www.kidney.de/pget.php?&tw=1&pmid=33846275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33846275 #FOAvip English Wikipedia <ref>{{Cite pmid|33846275}}</ref> Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19 #MMPMID33846275 Saris A; Reijnders TDY; Nossent EJ; Schuurman AR; Verhoeff J; Asten SV; Bontkes H; Blok S; Duitman J; Bogaard HJ; Heunks L; Lutter R; van der Poll T; Garcia Vallejo JJ Thorax 2021[Oct]; 76 (10): 1010-1019 PMID33846275show ga BACKGROUND: Knowledge of the pathophysiology of COVID-19 is almost exclusively derived from studies that examined the immune response in blood. We here aimed to analyse the pulmonary immune response during severe COVID-19 and to compare this with blood responses. METHODS: This was an observational study in patients with COVID-19 admitted to the intensive care unit (ICU). Mononuclear cells were purified from bronchoalveolar lavage fluid (BALF) and blood, and analysed by spectral flow cytometry; inflammatory mediators were measured in BALF and plasma. FINDINGS: Paired blood and BALF samples were obtained from 17 patients, four of whom died in the ICU. Macrophages and T cells were the most abundant cells in BALF, with a high percentage of T cells expressing the ydelta T cell receptor. In the lungs, both CD4 and CD8 T cells were predominantly effector memory cells (87.3% and 83.8%, respectively), and these cells expressed higher levels of the exhaustion marker programmad death-1 than in peripheral blood. Prolonged ICU stay (>14 days) was associated with a reduced proportion of activated T cells in peripheral blood and even more so in BALF. T cell activation in blood, but not in BALF, was higher in fatal COVID-19 cases. Increased levels of inflammatory mediators were more pronounced in BALF than in plasma. INTERPRETATION: The bronchoalveolar immune response in COVID-19 has a unique local profile that strongly differs from the immune profile in peripheral blood. Fully elucidating COVID-19 pathophysiology will require investigation of the pulmonary immune response. |Aged[MESH] |Bronchoalveolar Lavage Fluid/chemistry/cytology[MESH] |COVID-19/blood/*immunology/pathology[MESH] |Critical Care[MESH] |Critical Illness[MESH] |Female[MESH] |Flow Cytometry[MESH] |Humans[MESH] |Immunity, Cellular/*physiology[MESH] |Inflammation Mediators/*metabolism[MESH] |Macrophages/physiology[MESH] |Male[MESH] |Middle Aged[MESH]Distinct cellular immune profiles in the airways and blood of critical(epmc).pdf DeepDyve Pubget Overpricing