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Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Science 2021 ; 372 (6543): 738-741 Nephropedia Template TP
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Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues #MMPMID33846272
Yang F; Nielsen SCA; Hoh RA; Roltgen K; Wirz OF; Haraguchi E; Jean GH; Lee JY; Pham TD; Jackson KJL; Roskin KM; Liu Y; Nguyen K; Ohgami RS; Osborne EM; Nadeau KC; Niemann CU; Parsonnet J; Boyd SD
Science 2021[May]; 372 (6543): 738-741 PMID33846272show ga
Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated pediatric and adult blood and deceased adult organ donor tissues to determine convergent antigen-specific antibody genes of similar sequences shared between individuals. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, prepandemic children had class-switched convergent clones to severe acute respiratory syndrome coronavirus 2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. These results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.