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10.1126/science.abf6648

http://scihub22266oqcxt.onion/10.1126/science.abf6648
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33846272!8139427!33846272
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suck abstract from ncbi


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pmid33846272      Science 2021 ; 372 (6543): 738-741
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  • Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues #MMPMID33846272
  • Yang F; Nielsen SCA; Hoh RA; Roltgen K; Wirz OF; Haraguchi E; Jean GH; Lee JY; Pham TD; Jackson KJL; Roskin KM; Liu Y; Nguyen K; Ohgami RS; Osborne EM; Nadeau KC; Niemann CU; Parsonnet J; Boyd SD
  • Science 2021[May]; 372 (6543): 738-741 PMID33846272show ga
  • Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated pediatric and adult blood and deceased adult organ donor tissues to determine convergent antigen-specific antibody genes of similar sequences shared between individuals. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, prepandemic children had class-switched convergent clones to severe acute respiratory syndrome coronavirus 2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. These results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.
  • |*Immunologic Memory[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Aging[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |B-Lymphocytes/*immunology[MESH]
  • |Child, Preschool[MESH]
  • |Coronavirus/*immunology[MESH]
  • |Cross Reactions[MESH]
  • |Ebolavirus/immunology[MESH]
  • |Female[MESH]
  • |Fetal Blood/immunology[MESH]
  • |Genes, Immunoglobulin[MESH]
  • |Humans[MESH]
  • |Immunoglobulin Class Switching[MESH]
  • |Immunoglobulin D/genetics/immunology[MESH]
  • |Immunoglobulin Heavy Chains/immunology[MESH]
  • |Immunoglobulin M/genetics/immunology[MESH]
  • |Infant[MESH]
  • |Lymph Nodes/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Receptors, Antigen, B-Cell/immunology[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Somatic Hypermutation, Immunoglobulin[MESH]
  • |Spleen/immunology[MESH]


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