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10.1016/j.vph.2021.106861 http://scihub22266oqcxt.onion/10.1016/j.vph.2021.106861 33845201!8061373!33845201     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Vascul+Pharmacol 2021 ; 140 (ä): 106861 Nephropedia Template TP {{tp|p=33845201|t=2021. COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like receptor 3?|pdf=|usr=}}{{33845201}} gab.com Text COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like receptor 3 JO: Vascul Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33845201 #FOAvip The virus responsible for the coronavirus disease of 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidences suggest that COVID-19 could trigger cardiovascular complications in apparently healthy patients. Coronaviruses are enveloped positive-strand RNA viruses acting as a pathogen-associated molecular pattern (PAMP)/ danger-associated molecular patterns (DAMP). Interestingly, Toll-like receptor (TLR) 3 recognize both PAMPs DAMPs and is activated by viral double-stranded RNA (dsRNA) leading to activation of TIR receptor domain-containing adaptor inducing IFN-beta (TRIF) dependent pathway. New evidence has shown a link between virus dsRNA and increased BP. Hence, we hypothesize that COVID-19 infection may be over activating the TLR3 through dsRNA, evoking further damage to the patients, leading to vascular inflammation and increased blood pressure, favoring the development of several cardiovascular complications, including hypertension. Twit Text FOAVip COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like receptor 3 ????Vascul Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33845201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33845201 #FOAvip English Wikipedia <ref>{{Cite pmid|33845201}}</ref> COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like receptor 3? #MMPMID33845201 Dela Justina V; Giachini FR; Priviero F; Webb RC Vascul Pharmacol 2021[Oct]; 140 (ä): 106861 PMID33845201show ga The virus responsible for the coronavirus disease of 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidences suggest that COVID-19 could trigger cardiovascular complications in apparently healthy patients. Coronaviruses are enveloped positive-strand RNA viruses acting as a pathogen-associated molecular pattern (PAMP)/ danger-associated molecular patterns (DAMP). Interestingly, Toll-like receptor (TLR) 3 recognize both PAMPs DAMPs and is activated by viral double-stranded RNA (dsRNA) leading to activation of TIR receptor domain-containing adaptor inducing IFN-beta (TRIF) dependent pathway. New evidence has shown a link between virus dsRNA and increased BP. Hence, we hypothesize that COVID-19 infection may be over activating the TLR3 through dsRNA, evoking further damage to the patients, leading to vascular inflammation and increased blood pressure, favoring the development of several cardiovascular complications, including hypertension. |Animals[MESH] |COVID-19/*genetics/*pathology[MESH] |Humans[MESH] |Hypertension/*genetics/pathology/virology[MESH] |Mice[MESH] |RNA, Double-Stranded/*genetics[MESH] |SARS-CoV-2/pathogenicity[MESH] |Signal Transduction/genetics[MESH]COVID-19 and hypertension: Is there a role for dsRNA and activation of(epmc).pdf DeepDyve Pubget Overpricing