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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Invest 2021 ; 131 (10): ä Nephropedia Template TP
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SARS-CoV-2 as a superantigen in multisystem inflammatory syndrome in children #MMPMID33844652
Kouo T; Chaisawangwong W
J Clin Invest 2021[May]; 131 (10): ä PMID33844652show ga
Multisystem inflammatory syndrome in children (MIS-C) is a rare but deadly new disease in children that rapidly progresses to hyperinflammation and shock, and can lead to multiple organ failure if unrecognized. It has been found to be temporally associated with the COVID-19 pandemic and is often associated with SARS-CoV-2 exposure in children. In this issue of the JCI, Porritt, Paschold, et al. identify restricted T cell receptor (TCR) beta-chain variable domain (Vbeta) usage in patients with severe MIS-C, indicating a potential role for SARS-CoV-2 as a superantigen. These findings suggest that a blood test that determines the presence of specific TCRbeta variable gene (TRBV) segments may identify patients at risk for severe MIS-C.