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10.1016/j.xcrm.2021.100253 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100253 33842901!8020863!33842901     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (4): 100253 Nephropedia Template TP {{tp|p=33842901|t=2021. Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19 |pdf=|usr=}}{{33842901}} gab.com Text Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19 JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33842901 #FOAvip The fate of protective immunity following mild severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection remains ill defined. Here, we characterize antibody responses in a cohort of participants recovered from mild SARS-CoV-2 infection with follow-up to 6 months. We measure immunoglobulin A (IgA), IgM, and IgG binding and avidity to viral antigens and assess neutralizing antibody responses over time. Furthermore, we correlate the effect of fever, gender, age, and time since symptom onset with antibody responses. We observe that total anti-S trimer, anti-receptor-binding domain (RBD), and anti-nucleocapsid protein (NP) IgG are relatively stable over 6 months of follow-up, that anti-S and anti-RBD avidity increases over time, and that fever is associated with higher levels of antibodies. However, neutralizing antibody responses rapidly decay and are strongly associated with declines in IgM levels. Thus, while total antibody against SARS-CoV-2 may persist, functional antibody, particularly IgM, is rapidly lost. These observations have implications for the duration of protective immunity following mild SARS-CoV-2 infection. Twit Text FOAVip Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19 ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33842901 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33842901 #FOAvip English Wikipedia <ref>{{Cite pmid|33842901}}</ref> Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19 #MMPMID33842901 Harrington WE; Trakhimets O; Andrade DV; Dambrauskas N; Raappana A; Jiang Y; Houck J; Selman W; Yang A; Vigdorovich V; Yeung W; Haglund M; Wallner J; Oldroyd A; Hardy S; Stewart SWA; Gervassi A; Van Voorhis W; Frenkel L; Sather DN Cell Rep Med 2021[Apr]; 2 (4): 100253 PMID33842901show ga The fate of protective immunity following mild severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection remains ill defined. Here, we characterize antibody responses in a cohort of participants recovered from mild SARS-CoV-2 infection with follow-up to 6 months. We measure immunoglobulin A (IgA), IgM, and IgG binding and avidity to viral antigens and assess neutralizing antibody responses over time. Furthermore, we correlate the effect of fever, gender, age, and time since symptom onset with antibody responses. We observe that total anti-S trimer, anti-receptor-binding domain (RBD), and anti-nucleocapsid protein (NP) IgG are relatively stable over 6 months of follow-up, that anti-S and anti-RBD avidity increases over time, and that fever is associated with higher levels of antibodies. However, neutralizing antibody responses rapidly decay and are strongly associated with declines in IgM levels. Thus, while total antibody against SARS-CoV-2 may persist, functional antibody, particularly IgM, is rapidly lost. These observations have implications for the duration of protective immunity following mild SARS-CoV-2 infection. |Adult[MESH] |Aged[MESH] |Antibodies, Neutralizing/blood/immunology/*metabolism[MESH] |COVID-19/complications/*immunology/pathology/virology[MESH] |Female[MESH] |Fever/etiology[MESH] |Humans[MESH] |Immunoglobulin G/blood/immunology/metabolism[MESH] |Immunoglobulin M/blood/immunology/*metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Neutralization Tests[MESH] |Nucleocapsid Proteins/immunology[MESH] |Protein Domains/immunology[MESH] |Protein Multimerization/immunology[MESH] |SARS-CoV-2/immunology/isolation & purification[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/chemistry/immunology[MESH] |Time Factors[MESH]Rapid decline of neutralizing antibodies is associated with decay of I(epmc).pdf DeepDyve Pubget Overpricing