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10.1016/j.heliyon.2021.e06706

http://scihub22266oqcxt.onion/10.1016/j.heliyon.2021.e06706
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33842709!8020058!33842709
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suck abstract from ncbi

pmid33842709      Heliyon 2021 ; 7 (4): e06706
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  • Clinical characteristics and outcomes of COVID-19 patients with diabetes mellitus in Kuwait #MMPMID33842709
  • Alshukry A; Bu Abbas M; Ali Y; Alahmad B; Al-Shammari AA; Alhamar G; Abu-Farha M; AbuBaker J; Devarajan S; Dashti AA; Al-Mulla F; Ali H
  • Heliyon 2021[Apr]; 7 (4): e06706 PMID33842709show ga
  • BACKGROUND: COVID-19 has a highly variable clinical presentation, ranging from asymptomatic to severe respiratory symptoms and death. Diabetes seems to be one of the main comorbidities contributing to a worse COVID-19 outcome. OBJECTIVE: In here we analyze the clinical characteristics and outcomes of diabetic COVID-19 patients Kuwait. METHODS: In this single-center, retrospective study of 417 consecutive COVID-19 patients, we analyze and compare disease severity, outcome, associated complications, and clinical laboratory findings between diabetic and non-diabetic COVID-19 patients. RESULTS: COVID-19 patients with diabetes had more ICU admission than non-diabetic COVID-19 patients (20.1% vs. 16.8%, p < 0.001). Diabetic COVID-19 patients also recorded higher mortality in comparison to non-diabetic COVID-19 patients (16.7% vs. 12.1%, p < 0.001). Diabetic COVID-19 patients had significantly higher prevalence of comorbidities, such as hypertension. Laboratory investigations also highlighted notably higher levels of C-reactive protein in diabetic COVID019 patients and lower estimated glomerular filtration rate. They also showed a higher incidence of complications. logistic regression analysis showed that every 1 mmol/L increase in fasting blood glucose in COVID-19 patients is associated with 1.52 (95% CI: 1.34-1.72, p < 0.001) times the odds of dying from COVID-19. CONCLUSION: Diabetes is a major contributor to worsening outcomes in COVID-19 patients. Understanding the pathophysiology underlining these findings could provide insight into better management and improved outcome of such cases.
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