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http://scihub22266oqcxt.onion/ 33841649!8014342!33841649     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33841649&cmd=llinks): Failed to open stream: HTTP request failed! 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Correlation of the ratio of IgM/IgG concentration to days after symptom onset (IgM/T or IgG/T) with disease severity and outcome in non-critical COVID-19 patients |pdf=|usr=}}{{33841649}} gab.com Text Correlation of the ratio of IgM/IgG concentration to days after symptom onset (IgM/T or IgG/T) with disease severity and outcome in non-critical COVID-19 patients JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=33841649 #FOAvip BACKGROUND: Correlation of SARS-CoV-2 serum antibodies with COVID-19 development and outcome has not been fully studied. Due to the time dynamic of antibodies, the antibody concentration of the same patient varies greatly at different times during the course of the disease. Therefore, our study used IgM/T or IgG/T (the ratio of serum antibody concentration to days after symptom onset) to reflect the patient's humoral immune status, and analyzed their correlation with COVID-19 development and outcome. METHODS: Clinical data of 50 non-critical COVID-19 patients were retrospectively analyzed. Time-resolved fluorescence immunochromatography was used to quantitatively detect SARS-CoV-2 IgM and IgG. Correlation analysis was performed. RESULTS: IgM antibody was positive on day 5 of symptom onset, increased within 2 weeks, and then gradually decreased. However, IgG antibody was positive on week 2 of symptom onset and continued to increase since. Additionally, IgM/T, but not IgG/T of recovery period (Spearman rho=0.17; P=0.283), was negatively correlated with disease course in 2 weeks of symptom onset (Spearman rho=-0.860; P=0.000). IgG/T of recovery period was positively correlated with clinical classification (Spearman rho=0.432; P=0.004), number of involved lung lobes (Spearman rho=0.343; P=0.026), and lung lesions (Spearman rho=0.472; P=0.002). CONCLUSIONS: Within 2 weeks of symptom onset, higher IgM/T indicates faster recovery and shorter disease course. In recovery period, higher IgG/T suggests more serious disease. IgM/T or IgG/T may predict disease severity and outcome in non-critical COVID-19 patients. Twit Text FOAVip Correlation of the ratio of IgM/IgG concentration to days after symptom onset (IgM/T or IgG/T) with disease severity and outcome in non-critical COVID-19 patients ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=33841649 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33841649 #FOAvip English Wikipedia <ref>{{Cite pmid|33841649}}</ref> Correlation of the ratio of IgM/IgG concentration to days after symptom onset (IgM/T or IgG/T) with disease severity and outcome in non-critical COVID-19 patients #MMPMID33841649 Rong Y; Wang F; Li X; Liang X; Zhou Y; Zhang D; Liu J; Zeng H; Wang J; Shi Y Am J Transl Res 2021[]; 13 (3): 1197-1208 PMID33841649show ga BACKGROUND: Correlation of SARS-CoV-2 serum antibodies with COVID-19 development and outcome has not been fully studied. Due to the time dynamic of antibodies, the antibody concentration of the same patient varies greatly at different times during the course of the disease. Therefore, our study used IgM/T or IgG/T (the ratio of serum antibody concentration to days after symptom onset) to reflect the patient's humoral immune status, and analyzed their correlation with COVID-19 development and outcome. METHODS: Clinical data of 50 non-critical COVID-19 patients were retrospectively analyzed. Time-resolved fluorescence immunochromatography was used to quantitatively detect SARS-CoV-2 IgM and IgG. Correlation analysis was performed. RESULTS: IgM antibody was positive on day 5 of symptom onset, increased within 2 weeks, and then gradually decreased. However, IgG antibody was positive on week 2 of symptom onset and continued to increase since. Additionally, IgM/T, but not IgG/T of recovery period (Spearman rho=0.17; P=0.283), was negatively correlated with disease course in 2 weeks of symptom onset (Spearman rho=-0.860; P=0.000). IgG/T of recovery period was positively correlated with clinical classification (Spearman rho=0.432; P=0.004), number of involved lung lobes (Spearman rho=0.343; P=0.026), and lung lesions (Spearman rho=0.472; P=0.002). CONCLUSIONS: Within 2 weeks of symptom onset, higher IgM/T indicates faster recovery and shorter disease course. In recovery period, higher IgG/T suggests more serious disease. IgM/T or IgG/T may predict disease severity and outcome in non-critical COVID-19 patients. äCorrelation of the ratio of IgM/IgG concentration to days after sympto(epmc).pdf DeepDyve Pubget Overpricing