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10.1016/j.ebiom.2021.103319 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2021.103319 33840632!8027908!33840632     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33840632&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2021 ; 66 (ä): 103319 Nephropedia Template TP {{tp|p=33840632|t=2021. Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study |pdf=|usr=}}{{33840632}} gab.com Text Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=33840632 #FOAvip BACKGROUND: Host determinants of severe coronavirus disease 2019 include advanced age, comorbidities and male sex. Virologic factors may also be important in determining clinical outcome and transmission rates, but limited patient-level data is available. METHODS: We conducted an observational cohort study at seven public hospitals in Singapore. Clinical and laboratory data were collected and compared between individuals infected with different SARS-CoV-2 clades. Firth's logistic regression was used to examine the association between SARS-CoV-2 clade and development of hypoxia, and quasi-Poisson regression to compare transmission rates. Plasma samples were tested for immune mediator levels and the kinetics of viral replication in cell culture were compared. FINDINGS: 319 patients with PCR-confirmed SARS-CoV-2 infection had clinical and virologic data available for analysis. 29 (9%) were infected with clade S, 90 (28%) with clade L/V, 96 (30%) with clade G (containing D614G variant), and 104 (33%) with other clades 'O' were assigned to lineage B.6. After adjusting for age and other covariates, infections with clade S (adjusted odds ratio (aOR) 0.030 (95% confidence intervals (CI): 0.0002-0.29)) or clade O (B.6) (aOR 0.26 (95% CI 0.064-0.93)) were associated with lower odds of developing hypoxia requiring supplemental oxygen compared with clade L/V. Patients infected with clade L/V had more pronounced systemic inflammation with higher concentrations of pro-inflammatory cytokines, chemokines and growth factors. No significant difference in the severity of clade G infections was observed (aOR 0.95 (95% CI: 0.35-2.52). Though viral loads were significantly higher, there was no evidence of increased transmissibility of clade G, and replicative fitness in cell culture was similar for all clades. INTERPRETATION: Infection with clades L/V was associated with increased severity and more systemic release of pro-inflammatory cytokines. Infection with clade G was not associated with changes in severity, and despite higher viral loads there was no evidence of increased transmissibility. Twit Text FOAVip Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=33840632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33840632 #FOAvip English Wikipedia <ref>{{Cite pmid|33840632}}</ref> Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study #MMPMID33840632 Young BE; Wei WE; Fong SW; Mak TM; Anderson DE; Chan YH; Pung R; Heng CS; Ang LW; Zheng AKE; Lee B; Kalimuddin S; Pada S; Tambyah PA; Parthasarathy P; Tan SY; Sun L; Smith GJ; Lin RTP; Leo YS; Renia L; Wang LF; Ng LF; Maurer-Stroh S; Lye DC; Lee VJ EBioMedicine 2021[Apr]; 66 (ä): 103319 PMID33840632show ga BACKGROUND: Host determinants of severe coronavirus disease 2019 include advanced age, comorbidities and male sex. Virologic factors may also be important in determining clinical outcome and transmission rates, but limited patient-level data is available. METHODS: We conducted an observational cohort study at seven public hospitals in Singapore. Clinical and laboratory data were collected and compared between individuals infected with different SARS-CoV-2 clades. Firth's logistic regression was used to examine the association between SARS-CoV-2 clade and development of hypoxia, and quasi-Poisson regression to compare transmission rates. Plasma samples were tested for immune mediator levels and the kinetics of viral replication in cell culture were compared. FINDINGS: 319 patients with PCR-confirmed SARS-CoV-2 infection had clinical and virologic data available for analysis. 29 (9%) were infected with clade S, 90 (28%) with clade L/V, 96 (30%) with clade G (containing D614G variant), and 104 (33%) with other clades 'O' were assigned to lineage B.6. After adjusting for age and other covariates, infections with clade S (adjusted odds ratio (aOR) 0.030 (95% confidence intervals (CI): 0.0002-0.29)) or clade O (B.6) (aOR 0.26 (95% CI 0.064-0.93)) were associated with lower odds of developing hypoxia requiring supplemental oxygen compared with clade L/V. Patients infected with clade L/V had more pronounced systemic inflammation with higher concentrations of pro-inflammatory cytokines, chemokines and growth factors. No significant difference in the severity of clade G infections was observed (aOR 0.95 (95% CI: 0.35-2.52). Though viral loads were significantly higher, there was no evidence of increased transmissibility of clade G, and replicative fitness in cell culture was similar for all clades. INTERPRETATION: Infection with clades L/V was associated with increased severity and more systemic release of pro-inflammatory cytokines. Infection with clade G was not associated with changes in severity, and despite higher viral loads there was no evidence of increased transmissibility. |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |COVID-19/epidemiology/*etiology/immunology/*transmission[MESH] |Comorbidity[MESH] |Female[MESH] |Humans[MESH] |Hypoxia/therapy/virology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*genetics/*pathogenicity[MESH] |Singapore/epidemiology[MESH]Association of SARS-CoV-2 clades with clinical, inflammatory and virol(epmc).pdf DeepDyve Pubget Overpricing