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10.1016/j.cyto.2021.155523 http://scihub22266oqcxt.onion/10.1016/j.cyto.2021.155523 33840589!8011640!33840589     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cytokine 2021 ; 143 (ä): 155523 Nephropedia Template TP {{tp|p=33840589|t=2021. Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity |pdf=|usr=}}{{33840589}} gab.com Text Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity JO: Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=33840589 #FOAvip Cytokines play pleiotropic, antagonistic, and collaborative in viral disease. The high morbidity and mortality of coronavirus disease 2019 (COVID-19) make it a significant threat to global public health. Elucidating its pathogenesis is essential to finding effective therapy. A retrospective study was conducted on 71 patients hospitalized with COVID-19. Data on cytokines, T lymphocytes, and other clinical and laboratory characteristics were collected from patients with variable disease severity. The effects of cytokines on the overall survival (OS) and event-free survival (EFS) of patients were analyzed. The critically severe and severe patients had higher infection indexes and significant multiple organ function abnormalities than the mild patients (P < 0.05). IL-6 and IL-10 were significantly higher in the critically severe patients than in the severe and mild patients (P < 0.05). IL-6 and IL-10 were closely associated with white blood cells, neutrophils, T lymphocyte subsets, D-D dimer, blood urea nitrogen, complement C1q, procalcitonin C-reactive protein. Moreover, the IL-6 and IL-10 levels were closely correlated to dyspnea and dizziness (P < 0.05). The patients with higher IL-10 levels had shorter OS than the group with lower levels (P < 0.05). The older patients with higher levels of single IL-6 or IL-10 tended to have shorter EFS (P < 0.05), while the patients who had more elevated IL-6 and IL-10 had shorter OS (P < 0.05). The Cox proportional hazard model revealed that IL-6 was the independent factor affecting EFS. IL-6 and IL-10 play crucial roles in COVID-19 prognosis. Twit Text FOAVip Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity ????Cytokine http://www.kidney.de/pget.php?&tw=1&pmid=33840589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33840589 #FOAvip English Wikipedia <ref>{{Cite pmid|33840589}}</ref> Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity #MMPMID33840589 Tang Y; Sun J; Pan H; Yao F; Yuan Y; Zeng M; Ye G; Yang G; Zheng B; Fan J; Pan Y; Zhao Z; Guo S; Liu Y; Liao F; Duan Y; Jiao X; Li Y Cytokine 2021[Jul]; 143 (ä): 155523 PMID33840589show ga Cytokines play pleiotropic, antagonistic, and collaborative in viral disease. The high morbidity and mortality of coronavirus disease 2019 (COVID-19) make it a significant threat to global public health. Elucidating its pathogenesis is essential to finding effective therapy. A retrospective study was conducted on 71 patients hospitalized with COVID-19. Data on cytokines, T lymphocytes, and other clinical and laboratory characteristics were collected from patients with variable disease severity. The effects of cytokines on the overall survival (OS) and event-free survival (EFS) of patients were analyzed. The critically severe and severe patients had higher infection indexes and significant multiple organ function abnormalities than the mild patients (P < 0.05). IL-6 and IL-10 were significantly higher in the critically severe patients than in the severe and mild patients (P < 0.05). IL-6 and IL-10 were closely associated with white blood cells, neutrophils, T lymphocyte subsets, D-D dimer, blood urea nitrogen, complement C1q, procalcitonin C-reactive protein. Moreover, the IL-6 and IL-10 levels were closely correlated to dyspnea and dizziness (P < 0.05). The patients with higher IL-10 levels had shorter OS than the group with lower levels (P < 0.05). The older patients with higher levels of single IL-6 or IL-10 tended to have shorter EFS (P < 0.05), while the patients who had more elevated IL-6 and IL-10 had shorter OS (P < 0.05). The Cox proportional hazard model revealed that IL-6 was the independent factor affecting EFS. IL-6 and IL-10 play crucial roles in COVID-19 prognosis. |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |Aging[MESH] |Blood Coagulation Factors/analysis[MESH] |COVID-19/*blood/mortality/*pathology/therapy[MESH] |Cytokine Release Syndrome/pathology[MESH] |Female[MESH] |Humans[MESH] |Interleukin-10/*blood[MESH] |Interleukin-6/*blood[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Retrospective Studies[MESH] |SARS-CoV-2/immunology[MESH] |Severity of Illness Index[MESH] |Survival Analysis[MESH] |T-Lymphocyte Subsets/cytology/*immunology[MESH] |Thromboembolism/pathology[MESH]Aberrant cytokine expression in COVID-19 patients: Associations betwee(epmc).pdf DeepDyve Pubget Overpricing