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10.1016/j.ygeno.2021.04.002 http://scihub22266oqcxt.onion/10.1016/j.ygeno.2021.04.002 33838280!8025598!33838280     free     free     free       Genomics 2021 ; 113 (4): 1733-1741 Nephropedia Template TP {{tp|p=33838280|t=2021. Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality |pdf=|usr=}}{{33838280}} gab.com Text Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality JO: Genomics http://www.kidney.de/pget.php?&tw=1&pmid=33838280 #FOAvip Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population. We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01-2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16-4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNgamma were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. Twit Text FOAVip Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality ????Genomics http://www.kidney.de/pget.php?&tw=1&pmid=33838280 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33838280 #FOAvip English Wikipedia <ref>{{Cite pmid|33838280}}</ref> Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality #MMPMID33838280 Alghamdi J; Alaamery M; Barhoumi T; Rashid M; Alajmi H; Aljasser N; Alhendi Y; Alkhalaf H; Alqahtani H; Algablan O; Alshaya AI; Tashkandi N; Massadeh S; Almuzzaini B; Ehaideb SN; Bosaeed M; Ayoub K; Yezli S; Khan A; Alaskar A; Bouchama A Genomics 2021[Jul]; 113 (4): 1733-1741 PMID33838280show ga Interferon-induced membrane proteins (IFITM) 3 gene variants are known risk factor for severe viral diseases. We examined whether IFITM3 variant may underlie the heterogeneous clinical outcomes of SARS-CoV-2 infection-induced COVID-19 in large Arab population. We genotyped 880 Saudi patients; 93.8% were PCR-confirmed SARS-CoV-2 infection, encompassing most COVID-19 phenotypes. Mortality at 90 days was 9.1%. IFITM3-SNP, rs12252-G allele was associated with hospital admission (OR = 1.65 [95% CI; 1.01-2.70], P = 0.04]) and mortality (OR = 2.2 [95% CI; 1.16-4.20], P = 0.01). Patients less than 60 years old had a lower survival probability if they harbor this allele (log-rank test P = 0.002). Plasma levels of IFNgamma were significantly lower in a subset of patients with AG/GG genotypes than patients with AA genotype (P = 0.00016). Early identification of these individuals at higher risk of death may inform precision public health response. |*Genetic Predisposition to Disease[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/*genetics/mortality/virology[MESH] |Female[MESH] |Genetic Association Studies[MESH] |Genotype[MESH] |Humans[MESH] |Interferons/genetics[MESH] |Male[MESH] |Membrane Proteins/*genetics[MESH] |Middle Aged[MESH] |Polymorphism, Single Nucleotide/genetics[MESH] |RNA-Binding Proteins/*genetics[MESH]Interferon-induced transmembrane protein-3 genetic variant rs12252 is (epmc).pdf DeepDyve Pubget Overpricing