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10.1016/j.fct.2021.112184 http://scihub22266oqcxt.onion/10.1016/j.fct.2021.112184 33838172!8026244!33838172     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Food+Chem+Toxicol 2021 ; 152 (ä): 112184 Nephropedia Template TP {{tp|p=33838172|t=2021. Is SARS-CoV-2 Spike glycoprotein impairing macrophage function via alpha7-nicotinic acetylcholine receptors?|pdf=|usr=}}{{33838172}} gab.com Text Is SARS-CoV-2 Spike glycoprotein impairing macrophage function via alpha7-nicotinic acetylcholine receptors JO: Food Chem Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=33838172 #FOAvip The innate immune cells play an important role in handling early infections, and can eliminate them completely up to a certain threshold. Beyond that threshold they take up their role in "The Resolution of Inflammation". The recognition of the SARS-CoV-2 antigen triggers an eicosanoid storm and initiates a robust inflammatory response. This establishes a positive feedback loop which develops into a sustained cytokine storm which interferes with the activation of adaptive immune cells. The mechanism of this interaction, and hence the pathogenesis of the virus with the immune system, is yet to be determined. In silico studies predict a direct SARS-CoV-2 spike glycoprotein interaction with nicotinic acetylcholine receptors, which could impair macrophage function and initiate the cascade of events in severe infections. We here, add to the hypothesis that immune dysregulation can be caused by the interaction of the SARS-CoV-2 spike glycoprotein via a cryptic epitope with the alpha7-nAChR in Type-1 macrophages, discuss its implications for the treatment of COVID-19 patients, and present better prospects for the design and dissemination of more effective vaccines and their importance. Twit Text FOAVip Is SARS-CoV-2 Spike glycoprotein impairing macrophage function via alpha7-nicotinic acetylcholine receptors ????Food Chem Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=33838172 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33838172 #FOAvip English Wikipedia <ref>{{Cite pmid|33838172}}</ref> Is SARS-CoV-2 Spike glycoprotein impairing macrophage function via alpha7-nicotinic acetylcholine receptors? #MMPMID33838172 Tanmay S; Labrou D; Farsalinos K; Poulas K Food Chem Toxicol 2021[Jun]; 152 (ä): 112184 PMID33838172show ga The innate immune cells play an important role in handling early infections, and can eliminate them completely up to a certain threshold. Beyond that threshold they take up their role in "The Resolution of Inflammation". The recognition of the SARS-CoV-2 antigen triggers an eicosanoid storm and initiates a robust inflammatory response. This establishes a positive feedback loop which develops into a sustained cytokine storm which interferes with the activation of adaptive immune cells. The mechanism of this interaction, and hence the pathogenesis of the virus with the immune system, is yet to be determined. In silico studies predict a direct SARS-CoV-2 spike glycoprotein interaction with nicotinic acetylcholine receptors, which could impair macrophage function and initiate the cascade of events in severe infections. We here, add to the hypothesis that immune dysregulation can be caused by the interaction of the SARS-CoV-2 spike glycoprotein via a cryptic epitope with the alpha7-nAChR in Type-1 macrophages, discuss its implications for the treatment of COVID-19 patients, and present better prospects for the design and dissemination of more effective vaccines and their importance. |COVID-19/*immunology[MESH] |Epitopes[MESH] |Humans[MESH] |Macrophages/*virology[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH]Is SARS-CoV-2 Spike glycoprotein impairing macrophage function via alp(epmc).pdf DeepDyve Pubget Overpricing