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10.1002/jmv.27009 http://scihub22266oqcxt.onion/10.1002/jmv.27009 33837972!8250946!33837972     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Med+Virol 2021 ; 93 (7): 4258-4264 Nephropedia Template TP {{tp|p=33837972|t=2021. Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target |pdf=|usr=}}{{33837972}} gab.com Text Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target JO: J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33837972 #FOAvip The recent coronavirus disease 2019 (COVID-19), causing a global pandemic with devastating effects on healthcare and social-economic systems, has no special antiviral therapies available for human coronaviruses (CoVs). The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) possesses a nonstructural protein (nsp14), with amino-terminal domain coding for proofreading exoribonuclease (ExoN) that is required for high-fidelity replication. The ability of CoVs during genome replication and transcription to proofread and exclude mismatched nucleotides has long hindered the development of anti-CoV drugs. The resistance of SARS-CoV-2 to antivirals, especially nucleoside analogs (NAs), shows the need to identify new CoV inhibition targets. Therefore, this review highlights the importance of nsp14-ExoN as a target for inhibition. Also, nucleoside analogs could be used in combination with existing anti-CoV therapeutics to target the proofreading mechanism. Twit Text FOAVip Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target ????J Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=33837972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33837972 #FOAvip English Wikipedia <ref>{{Cite pmid|33837972}}</ref> Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target #MMPMID33837972 Tahir M J Med Virol 2021[Jul]; 93 (7): 4258-4264 PMID33837972show ga The recent coronavirus disease 2019 (COVID-19), causing a global pandemic with devastating effects on healthcare and social-economic systems, has no special antiviral therapies available for human coronaviruses (CoVs). The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) possesses a nonstructural protein (nsp14), with amino-terminal domain coding for proofreading exoribonuclease (ExoN) that is required for high-fidelity replication. The ability of CoVs during genome replication and transcription to proofread and exclude mismatched nucleotides has long hindered the development of anti-CoV drugs. The resistance of SARS-CoV-2 to antivirals, especially nucleoside analogs (NAs), shows the need to identify new CoV inhibition targets. Therefore, this review highlights the importance of nsp14-ExoN as a target for inhibition. Also, nucleoside analogs could be used in combination with existing anti-CoV therapeutics to target the proofreading mechanism. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/*pharmacology[MESH] |Exoribonucleases/drug effects/*genetics/metabolism[MESH] |Genome, Viral/genetics[MESH] |Humans[MESH] |Methyltransferases/genetics[MESH] |RNA Processing, Post-Transcriptional/physiology[MESH] |RNA, Viral/genetics[MESH] |SARS-CoV-2/drug effects/*genetics[MESH] |Viral Nonstructural Proteins/drug effects/*genetics/metabolism[MESH]Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potent(epmc).pdf DeepDyve Pubget Overpricing