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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Intern+Emerg+Med 2021 ; 16 (8): 2181-2191 Nephropedia Template TP
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A randomized clinical trial evaluating the immunomodulatory effect of convalescent plasma on COVID-19-related cytokine storm #MMPMID33837906
Pouladzadeh M; Safdarian M; Eshghi P; Abolghasemi H; Bavani AG; Sheibani B; Moradi Choghakabodi P; Feghhi A; Ghafourian Boroujerdnia M; Forouzan A; Jalali Far MA; Kaydani GA; Rajaei E; Amin M; Torabizadeh M; Yousefi F; Hadaddezfuli R
Intern Emerg Med 2021[Nov]; 16 (8): 2181-2191 PMID33837906show ga
Evaluating the effect of convalescent plasma (CP) on some cytokine storm indices in severe COVID-19 patients. Totally, 62 patients were randomly assigned into two groups for this clinical trial. Patients in the intervention group received one unit (500 mL) plasma on the admission day plus standard drugs while the controls merely received standard treatments. Eventually, primary and secondary outcomes were evaluated. In the CP group, compared with controls, the mean levels of lymphocytes and IL-10 significantly increased while the levels of IL-6, TNF-alpha, and IFN-gamma decreased (p < 0.05). The length of in-hospital stay, and mortality rate did not significantly reduce in the CP group compared with controls (p > 0.05) while WHO severity scores remarkably improved (p = 0.01), despite the higher frequency of underlying diseases among the CP group (66.7%) vs. controls (33.3%). Although CP has a remarkable immunomodulatory and antiviral potential to improve the cytokine storm and disease severity in COVID-19 patients, it did not considerably affect the mortality rate.